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TRIMETHYLBICYCLO-2-HEPTANOL.

Questionable CAS 512-13-0 / PERFUMING

TRIMETHYLBICYCLO-2-HEPTANOL is a bicyclic monoterpene alcohol, a volatile oil component primarily utilized for its fragrance and masking properties. While related to compounds offering cooling sensations, its key biological characteristic is a demonstrated potential for enhancing the permeability of biological membranes.

Summary

Fragrance Masking Permeation Enhancer Cooling Agent

Science

Mechanism of Action

As an isomer of Borneol, TRIMETHYLBICYCLO-2-HEPTANOL is theorized to function as a permeation enhancer. Studies on Borneol indicate its capacity to improve the transport of substances across biological barriers, such as the blood-brain barrier, suggesting a comparable ability to increase transdermal absorption of other active ingredients. Additionally, related compounds like Camphor are known to induce a cooling effect, along with mild local anesthetic and antimicrobial properties.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Borneol, an isomer of TRIMETHYLBICYCLO-2-HEPTANOL, was shown to enhance the transport of ginkgolides across the blood-brain barrier when incorporated into liposomes. This resulted in improved pharmacokinetic profiles and a high drug concentration (3.39 μg/g) in brain tissue. While indicative of permeation enhancement, direct clinical studies evaluating its topical skincare efficacy are currently unavailable.

Transparency

Dusting Analysis

Not commonly dusted

No data available to suggest TRIMETHYLBICYCLO-2-HEPTANOL is commonly 'dusted' or misused at inappropriate concentrations in skincare formulations.

The Formula

Formulation

Solubility
Oil
Optimal pH 7 – 7.4
0 7 14

Stability

Borneol (1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol), an isomer, exhibits stability under normal conditions with an approximate neutral pH of 7 in aqueous solution. Optimal formulation for borneol-modified liposomes was achieved in a phosphate buffer at pH 7.4, suggesting good stability and absorption within physiological pH ranges.

Conflicts

  • strong oxidizing agents
  • acids
  • some halogenated compounds

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

TRIMETHYLBICYCLO-2-HEPTANOL and its specific isomers like Borneol or Isofenchol have not been directly reviewed by the Cosmetic Ingredient Review (CIR). However, Borneol (CAS 507-70-0) has undergone a safety assessment by the Research Institute for Fragrance Materials (RIFM) as a fragrance ingredient and is approved by the FDA as a non-toxic flavoring agent for ingestion. Caution is warranted for topical applications due to irritancy; Isobornyl alcohol (1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol), an isomer, is classified as a 'Primary Irritant' by RTECS. Furthermore, Bornane (1,7,7-Trimethylbicyclo[2.2.1]heptane), a related compound, is associated with causing skin irritation (H315) and serious eye irritation (H319). Borneol also has a reported fatal oral dose (human) of 50-500 mg/kg, classifying it as 'very toxic', and is considered flammable; these notes primarily pertain to ingestion and handling safety, not typical topical use.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While TRIMETHYLBICYCLO-2-HEPTANOL demonstrates potential as a permeation enhancer and offers sensory benefits like fragrance and cooling, the absence of direct topical clinical efficacy data combined with documented irritancy concerns for its isomers makes its inclusion in precision skincare formulations seeking targeted benefits questionable.

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