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Moumoujus

TRIHYDROXYDIHYDROCHALCONE.

Insufficient Data CAS 23130-26-9 / SKIN CONDITIONING

TRIHYDROXYDIHYDROCHALCONE is a derivative within the chalcone/dihydrochalcone family, generally recognized for its antioxidant and anti-inflammatory properties. Research on closely related compounds suggests its potential for modulating skin pigmentation and offering protection against oxidative stress, positioning it as a prospective ingredient for advanced skincare formulations.

Summary

Antioxidant Anti-inflammatory Brightening UV Protectant

Science

Mechanism of Action

As a member of the chalcone/dihydrochalcone class, TRIHYDROXYDIHYDROCHALCONE is hypothesized to exert antioxidant and anti-inflammatory effects. Closely related compounds have demonstrated potent tyrosinase modulation, suggesting a role in addressing hyperpigmentation. Its anti-inflammatory action may involve the inhibition of pro-inflammatory mediators such as PGE2, NO, and TNF-α, while also contributing to protection against oxidative stress.

Research

Clinical Evidence

Low confidence
Effective range 50–100%
Optimal

N/A

Key findings

  1. 01 An in vitro study indicated that concentrations between 50-100 μM augmented TRAIL-induced apoptosis and cytotoxicity in LNCaP (human hormone-sensitive prostate cancer) cells. While biologically significant, this study does not directly demonstrate efficacy in healthy human skin for cosmetic applications.

Transparency

Dusting Analysis

Not commonly dusted

No data available to suggest dusting is a common issue for this ingredient.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Optimal pH range for TRIHYDROXYDIHYDROCHALCONE stability is not specifically documented. General chalcones are reported to be most stable at pH values exceeding 5, indicating near-neutral conditions. A related compound, neohesperidin dihydrochalcone, showed optimal stability at pH 4.50. While this compound is noted as oil-soluble, general flavonoids (including chalcones) often exhibit poor solubility in nonpolar solvents, which can pose formulation challenges for achieving desired bioavailability and penetration.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

No direct safety assessments by CIR, SCCS, or FDA are available for TRIHYDROXYDIHYDROCHALCONE. However, PubChem lists GHS classifications for the closely related 2',4',6'-Trihydroxydihydrochalcone, indicating it may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). INCIDecoder also rates its irritancy as medium.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While TRIHYDROXYDIHYDROCHALCONE belongs to a promising class of compounds with potential antioxidant, anti-inflammatory, and brightening effects, direct clinical evidence for its efficacy and safety in human skin remains insufficient, necessitating further dedicated research.

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