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Moumoujus

TRIFLUOROACETIC ACID.

Avoid CAS 76-05-1 / pH ADJUSTERS

Trifluoroacetic Acid (TFA) is an exceptionally strong acid, characterized by a pKa ranging from 0.23 to 0.52. It functions as a corrosive agent, inducing chemical exfoliation through the denaturation of skin proteins. This compound is also identified as a per- and polyfluoroalkyl substance (PFAS).

Summary

Exfoliant Keratolytic Agent

Science

Mechanism of Action

As a potent acid (pKa 0.23-0.52), Trifluoroacetic Acid exerts a corrosive effect on the skin, initiating chemical exfoliation by denaturing structural proteins. While effective for keratolysis, higher concentrations or extended application can lead to severe skin burns and tissue necrosis.

Research

Clinical Evidence

Low confidence
Effective range 0.1–20%
Optimal

N/A

Key findings

  1. 01 Exfoliating and keratolytic activity for treating hyperkeratotic skin lesions, with concentrations from 0.1% to 20% (w/w) cited, and 5% to 10% being most preferred.

Transparency

Dusting Analysis

Not commonly dusted

Trifluoroacetic Acid is primarily utilized as a chemical reagent and in medical treatments for specific skin conditions, not as a conventional cosmetic ingredient. Its highly corrosive nature and regulatory classification as a PFAS precursor, without direct cosmetic approval, indicate it is not 'dusted' in typical cosmetic formulations.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

An extremely strong acid (pKa 0.23-0.52), Trifluoroacetic Acid is hygroscopic and forms an azeotrope with water, necessitating careful formulation to maintain consistent concentration and purity.

Conflicts

  • Combustible materials
  • Strong bases (reacts violently)
  • Strong oxidizing agents
  • Alkali metals
  • Amines
  • Water (forms azeotrope, reacts with bases)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

Trifluoroacetic Acid is classified as a highly corrosive substance and a per- and polyfluoroalkyl substance (PFAS). Direct contact can cause severe skin burns, eye damage, and irritation to mucous membranes. The FDA identifies it as a precursor for some cosmetic PFAS derivatives but does not list TFA itself as a direct cosmetic ingredient, noting significant data gaps in dermal absorption and toxicity. There are no available CIR or SCCS reviews for Trifluoroacetic Acid in cosmetics.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Trifluoroacetic Acid is a highly corrosive substance with substantial safety concerns, categorized as a PFAS, and lacks established cosmetic approval, rendering it unsuitable for skincare formulations.

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