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Moumoujus

TRIETHYLENETETRAMINE HCL.

Avoid CAS 38260-01-4 / CHELATING

Triethylenetetramine HCl, also known as trientine hydrochloride, functions as a potent copper-chelating agent. Primarily recognized for its pharmaceutical application, it actively binds to excess metal ions, particularly copper, to facilitate their elimination from the body.

Summary

Chelating Agent Antioxidant

Science

Mechanism of Action

This compound primarily operates as a copper-chelating agent, forming stable complexes with metal ions, especially copper, which are then excreted. Its free base form, Triethylenetetramine (TETA), also demonstrates antioxidant activity by mitigating copper-mediated oxidative stress. Medical applications suggest it may also inhibit copper-induced secretion of interleukin-8 (IL-8), a pro-inflammatory cytokine.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No cosmetic uses or efficacy data for skincare formulations are reported, thus 'dusting' potential cannot be assessed.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Triethylenetetramine HCl exhibits significant sensitivity to water and humidity; levels exceeding 40% humidity are detrimental to its stability. Medical formulations are inherently unstable, often requiring strict cold chain storage, and aqueous solutions are not stable for storage beyond one day.

Conflicts

  • strong oxidizing agents
  • strong acids
  • high humidity (above 40%)

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk High

The Cosmetic Ingredient Review (CIR) Expert Panel has not assessed Triethylenetetramine HCl for cosmetic use, as no such uses have been reported. Its free base, Triethylenetetramine (TETA), is documented as severely irritating to the skin and eyes and can cause skin sensitization. Trientine hydrochloride, in its pharmaceutical form, has been associated with side effects including skin rash. Furthermore, it is listed on the California Safe Cosmetics Program (CSCP) Reportable Ingredient list for developmental toxicity, indicating potential risks during pregnancy.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given the absence of cosmetic safety evaluations, documented severe irritation and sensitization potential of its free base, concerns regarding developmental toxicity, and its extreme instability, this ingredient is not suitable for skincare formulations.

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