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Moumoujus

TRIDEC-2-ENENITRILE.

Avoid CAS 22629-49-8 / PERFUMING

TRIDEC-2-ENENITRILE is an organic nitrile primarily recognized for its role in fragrance formulations, serving as a modifier, masking agent, and fixative. While it is claimed to offer multiple skincare benefits such as antioxidant and anti-inflammatory properties, these assertions lack substantiation from clinical studies, and the ingredient presents significant safety concerns for direct skin application.

Summary

Perfuming Antioxidant Anti-inflammatory Collagen production Oil control Skin barrier support Masking agent Fixative

Science

Mechanism of Action

This compound is purported to exert antioxidant effects by neutralizing free radicals, alleviate skin irritation and redness through anti-inflammatory action, and support skin health by stimulating collagen production and reinforcing the skin barrier. Additionally, it is claimed to help regulate sebum production. Within cosmetic formulations, it also functions to modify, mask, or prolong the presence of fragrances.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

TRIDEC-2-ENENITRILE demonstrates robust stability under typical conditions and maintains good to excellent integrity across various cosmetic formulations including body lotions, shampoos, soaps, antiperspirant roll-ons, and powders. However, it exhibits poor stability when exposed to bleach.

Conflicts

  • strong oxidizing agents
  • strong acids

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk High

The Cosmetic Ingredient Review (CIR) has classified TRIDEC-2-ENENITRILE as having insufficient data for a full safety assessment as a direct cosmetic active. The Research Institute for Fragrance Materials (RIFM) assessed it for fragrance safety, concluding it is not expected to be genotoxic and establishing a reference dose of 0.67 mg/kg/day for repeated dose and reproductive toxicity. However, it is recognized as a skin sensitizer with a No Expected Sensitization Induction Level (NESIL) of 6900 μg/cm2, with its chemical structure indicating a propensity to react with skin proteins. It is classified as a hazardous substance by GHS, capable of causing skin and eye irritation, and potentially respiratory irritation. Prolonged or repeated exposure can lead to dermatitis. The commonly cited maximum concentration of 0.5000% is an IFRA recommendation specifically for fragrance concentrates and is not established as a general cosmetic safe limit for direct active use in skincare products. No specific regulatory approval (CIR, SCCS, FDA) for its use as a direct skincare active ingredient exists.

Your Skin

Skin Compatibility

No Normal
No Dry
Yes Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given the lack of clinical efficacy data for its claimed skin benefits and its classification as a confirmed skin sensitizer with irritation potential, TRIDEC-2-ENENITRILE is not recommended for use as a direct active ingredient in precision skincare formulations.

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