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Moumoujus

TREHANGELINS.

Valuable / SKIN CONDITIONING

Trehangelins (THG) are a sophisticated ingredient engineered to address inflammation-induced skin senescence. This compound precisely targets cellular communication pathways, enhancing the structural integrity of the skin's basement membrane and promoting vital cellular self-cleaning processes for comprehensive skin rejuvenation.

Summary

Anti-aging Skin Barrier Support Anti-inflammatory Collagen Regulation Cellular Detoxification

Science

Mechanism of Action

Trehangelins exert their effect by specifically inhibiting the nuclear translocation of Yes-Associated Protein (YAP), thereby suppressing the expression of epidermal Cellular Communication Network factor 1 (CCN1). This action ameliorates inflammation-induced skin senescence and regulates collagen homeostasis. Furthermore, THG activates autophagy, a crucial cellular mechanism for detoxification and maintaining optimal skin cell function.

Research

Clinical Evidence

Medium confidence
Effective range 0–1%
Optimal

N/A

Key findings

  1. 01 Topical application of Trehangelins within a 0-1% concentration range was shown to ameliorate the structure of the basement membrane in ex vivo human skin explants. It also effectively suppressed epidermal Cellular Communication Network factor 1 (CCN1) expression in ex vivo skin explants treated with plasmin and those exposed to UVB radiation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

No explicit optimal pH range for stability has been identified. Trehangelins consist of trehalose and two angelic acid moieties; while trehalose is water-soluble, the overall solubility is not specified. However, the physical properties of THG suggest high penetration of the stratum corneum, hinting at potential lipophilic characteristics.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific safety assessments by major regulatory bodies such as CIR, SCCS, or FDA have been found for Trehangelins.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Trehangelins demonstrate a precise, evidence-backed mechanism for combating skin senescence and improving structural integrity, making it a valuable addition for targeted anti-aging formulations, pending further safety and formulation optimization data.

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