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Moumoujus

TRANS, TRANS-2,4-DECADIENAL.

Avoid CAS 25152-84-5 / PERFUMING

Trans, trans-2,4-Decadienal is a highly reactive α,β-unsaturated aldehyde exhibiting both theoretical antioxidant potential and significant pro-oxidant activity within biological systems. It is identified as a compound of high concern by major health organizations due to its capacity to induce cellular damage and inflammation.

Summary

Science

Mechanism of Action

While possessing some theoretical antioxidant properties, Trans, trans-2,4-Decadienal acts predominantly as a potent pro-oxidant. It significantly elevates intracellular reactive oxygen species (ROS), leads to mitochondrial oxidative damage, and directly interacts with DNA and cytochrome c. This compound also inhibits cell growth, promotes M1 macrophage accumulation, stimulates the secretion of inflammatory cytokines, and ultimately induces apoptosis.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The ingredient is highly sensitive to light and air, demanding stringent storage under inert gas in a cool, dark environment, with a recommended temperature below 15°C.

Conflicts

  • Strong oxidizing agents
  • Fragrance applications (prohibited by IFRA)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

Trans, trans-2,4-Decadienal is categorized as a high-priority compound of concern by the U.S. National Cancer Institutes (NCI) and National Toxicology Program (NTP). GHS classifications indicate it is harmful in contact with skin, causes skin irritation, and causes serious eye irritation. The Expert Panel for Fragrance Safety (IFRA) explicitly prohibits its use as or in any fragrance ingredient in finished products due to safety concerns.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given its classification as a compound of high concern, significant irritancy potential, detrimental pro-oxidant mechanisms, and regulatory prohibitions, Trans, trans-2,4-Decadienal is unsuitable for precision skincare formulations and should be avoided.

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