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Moumoujus

TRANS-ROSE KETONE-5.

Questionable CAS 39872-57-6 / PERFUMING

TRANS-ROSE KETONE-5 is an aromatic compound belonging to the rose ketone family, primarily utilized for its distinctive fragrance profile in cosmetic and personal care products. While the broader class of rose ketones generally exhibits antioxidant and anti-inflammatory properties, specific clinical efficacy for this particular isomer in skincare remains largely unstudied.

Summary

Fragrance Ingredient Antioxidant Anti-inflammatory

Science

Mechanism of Action

As a member of the rose ketone chemical group, TRANS-ROSE KETONE-5 is theorized to possess antioxidant capabilities, aiding in the protection of skin from free radical damage. It may also contribute to anti-inflammatory processes, though its primary contribution to formulations is sensory.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.02%
Red flag below
0.02%

TRANS-ROSE KETONE-5 belongs to a group of chemicals (damascones/rose ketones) with a strict maximum concentration of 0.02% in finished cosmetic products, primarily due to dermal sensitization risks. Any inclusion above this precise threshold is a significant red flag, indicating potential non-compliance with safety guidelines rather than an increase in functional benefit.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

A related compound, 'trans-rose ketone-3', demonstrates significant hydrolytic stability with a half-life of 332 days, suggesting similar long-term stability for TRANS-ROSE KETONE-5 in formulations.

Conflicts

  • This ingredient is identified as a potential skin sensitizer and allergen, particularly problematic for individuals with known fragrance sensitivities. Formulators must exercise extreme caution to avoid adverse dermal reactions.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.02%
Sensitization risk High

TRANS-ROSE KETONE-5 has not undergone review by the CIR Expert Panel. However, the Scientific Committee on Consumer Safety (SCCS) has assessed related damascones ('trans-rose ketone-2' and 'trans-rose ketone-3'), restricting their use under Annex III of the EC Cosmetics Regulation to a maximum concentration of 0.02% in finished cosmetic products when combined with other damascone group chemicals. The Expert Panel for Fragrance Safety (RIFM) also reviews 'Rose ketones' for dermal sensitization and systemic toxicity. Damascones are generally considered moderate to strong skin sensitizers, with 'trans-ROSE KETONE-3' specifically linked to contact allergy in humans. The cumulative concentration of all rose ketone isomers must adhere to established safe levels.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Given its high potential for dermal sensitization, strict regulatory concentration limits, and unproven specific clinical efficacy for skincare benefits, TRANS-ROSE KETONE-5 is a questionable addition to precision skincare formulations, especially for those with sensitive skin.

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