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Moumoujus

TRANS-CINNAMONITRILE.

Avoid CAS 1885-38-7 / PERFUMING

Trans-Cinnamonitrile is an organic compound primarily recognized for its antibacterial properties, functioning by disrupting bacterial metabolism and growth. While used extensively as a fragrance component, its application in precision skincare requires careful consideration due to significant safety concerns.

Summary

Antibacterial agent Fragrance component

Science

Mechanism of Action

This compound exerts its antibacterial effects through multiple pathways, including the inhibition of dihydrofolate synthase, which consequently impedes folic acid synthesis crucial for bacterial proliferation. It further interferes with essential bacterial enzyme synthesis required for cell division, impacts bacterial RNA synthesis, and reduces cell membrane permeability, ultimately leading to bacterial metabolic disruption and death.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

There is no evidence of Trans-Cinnamonitrile being overhyped or 'dusted' in the skincare industry for specific benefits, as there are no clinical studies supporting its efficacy for common skincare concerns. Its primary known action is antibacterial, but this is overshadowed by its significant safety profile.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Chemically stable under normal conditions, but sensitive to both air and light exposure, necessitating storage in dark, airtight containers.

Conflicts

  • oxidizing agents

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.023%
Sensitization risk High

Aggregated safety data indicates Trans-Cinnamonitrile is toxic if swallowed, harmful upon skin contact, and can cause skin irritation, serious eye irritation, and respiratory irritation. Crucially, it is a known dermal sensitizer, carrying a high risk of allergic skin reactions. The International Fragrance Association (IFRA) restricts its use in cosmetics due to this sensitization risk, with specific limits varying by product category. For precision facial applications in leave-on moisturizers (Category 5B), the restriction limit is 0.11%, while a more restrictive limit of 0.023% applies to products used on the axillae (Category 2).

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite its established antibacterial properties, Trans-Cinnamonitrile presents a high risk of dermal sensitization and irritation, coupled with a complete lack of clinical efficacy data for targeted skincare benefits, rendering it unsuitable for precision skincare formulations.

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