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Moumoujus

TOLUENE-3,4-DIAMINE.

Avoid CAS 496-72-0 / HAIR DYEING

Toluene-3,4-diamine is an aromatic diamine primarily utilized as a colorant in hair dyeing formulations. Its application in cosmetic products, particularly for skin, is highly constrained due to significant safety concerns and insufficient data regarding its dermal effects.

Summary

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

This compound demonstrates stability under ambient conditions when stored in sealed containers. However, it is an air-sensitive solid requiring inert storage to prevent degradation and maintain its chemical integrity. Heating to elevated temperatures can induce decomposition, releasing toxic nitrogen oxides.

Conflicts

  • strong oxidizing agents
  • acids
  • isocyanates
  • halogenated organics
  • peroxides
  • phenols (acidic)
  • epoxides
  • anhydrides
  • acid halides

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk High

The Cosmetic Ingredient Review (CIR) Expert Panel has determined there are insufficient data to support the safety of toluene-3,4-diamine for use as a hair dye. Despite previous assessments, new evidence indicates potential variations in toxicity, particularly concerning carcinogenicity, when compared to structurally similar diamines. It is also documented as a significant irritant to both skin and eyes.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Toluene-3,4-diamine is not recommended for skincare due to insufficient safety data, documented high irritancy, and unresolved concerns regarding its potential toxicity, including carcinogenicity.

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