Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

THURFYL NICOTINATE.

Avoid CAS 70-19-9 / SKIN CONDITIONING

Thurfyl Nicotinate is a peripheral vasodilator that induces a warming sensation and visible redness on the skin by significantly increasing local blood circulation. Its pronounced effects, which include erythema and wealing, are primarily attributed to the release of nicotinic acid and may involve prostaglandin-like actions.

Summary

Peripheral Vasodilator Rubefacient Circulation Enhancer

Science

Mechanism of Action

Upon topical application, Thurfyl Nicotinate undergoes hydrolysis within the skin, releasing nicotinic acid (Vitamin B3). This liberated nicotinic acid acts as a potent peripheral vasodilator, leading to a noticeable increase in cutaneous blood flow and a characteristic flushing response. The induced inflammatory reaction, manifesting as erythema and wealing, is partially mediated by prostaglandin-like activity and a localized suppression of fibrinolysis.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Topical application in humans consistently induces erythema and wealing (cutaneous reactions).
  2. 02 Flushing responses are observed in guinea-pigs following topical application.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH 2 – 7
0 7 14

Stability

This ester exhibits optimal stability in acidic to slightly neutral pH environments, specifically within a range of 2.0 to 7.0. Degradation due to hydrolysis significantly accelerates under alkaline conditions.

Conflicts

  • strong oxidizing agents
  • strong bases
  • amines
  • strong reducing agents
  • highly alkaline excipients

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

Comprehensive safety assessments by regulatory bodies such as CIR (Cosmetic Ingredient Review) or SCCS (Scientific Committee on Consumer Safety) are not available for Thurfyl Nicotinate. The ingredient is known to induce significant cutaneous reactions and flushing, indicating a high potential for irritation, particularly in individuals with sensitive skin. Furthermore, chemically related compounds like Tetrahydrofurfuryl alcohol are identified as skin and eye irritants, and a suspected reproductive toxicant by ANSES.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given its high potential for inducing significant skin irritation and the absence of comprehensive safety reviews from cosmetic regulatory bodies, Thurfyl Nicotinate is not recommended for precision skincare formulations.

Related

Similar Ingredients

Finding similar ingredients…