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Moumoujus

THUJOPSIS DOLABRATA LEAF EXTRACT.

Optional CAS 91722-39-3 / PERFUMING

Derived from the leaves of the Thujopsis dolabrata tree, this extract is recognized for its multifaceted benefits, including anti-inflammatory, anti-allergic, and antioxidant properties. Preclinical research suggests its potential to soothe irritation and protect the skin from oxidative stress.

Summary

skin conditioning perfuming

Science

Mechanism of Action

Thujopsis Dolabrata Leaf Extract, specifically its essential oil component, operates through several pathways to support skin health. It demonstrates anti-inflammatory and anti-allergic effects by inhibiting the production of inflammatory mediators such as IgE and histamine, and by stabilizing mast cells to prevent their degranulation, thereby mitigating atopic dermatitis-like skin lesions. Furthermore, it exhibits significant antioxidant capabilities by neutralizing free radicals. Preliminary evidence also suggests potential antimicrobial activity.

Research

Clinical Evidence

Medium confidence
Effective range 1.5–11%
Optimal

N/A

Key findings

  1. 01 Essential oil concentrations of 1.5%, 3.0%, and 6.0% ameliorated atopic dermatitis-like skin lesions, inhibited mast cell infiltration, and reduced serum histamine and IgE levels in NC/Nga mice, indicating anti-inflammatory and anti-allergic effects.
  2. 02 An essential oil concentration of 11% (v/v) demonstrated a notable antioxidant effect (SC50) using the DPPH method.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) has not published a specific safety assessment for Thujopsis Dolabrata Leaf Extract, thus categorizing it as 'insufficient data' for a comprehensive review. While the EWG Skin Deep database assigns a 'LOW' hazard score across various concerns, this is not a formal regulatory assessment. Dermal toxicity for the leaf extract is currently undetermined.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Optional

This extract shows promising anti-inflammatory, anti-allergic, and antioxidant properties in preclinical studies, suggesting potential for sensitive and compromised skin, though further human clinical data is needed for definitive conclusions and safety assessment.

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