Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

THUJA PLICATA STEM OIL.

Valuable CAS 94334-32-4 / PERFUMING

Thuja Plicata Stem Oil, also known as Arborvitae essential oil, is a potent botanical extract recognized for its multi-functional properties, including significant anti-inflammatory, antimicrobial, and tissue remodeling support in precision skincare formulations. It operates effectively at extremely low concentrations to target various skin concerns from inflammation to scar appearance.

Summary

Antioxidant Antimicrobial Anti-inflammatory Skin Conditioning Hair Conditioning Perfuming Masking Tonic

Science

Mechanism of Action

This oil exerts its effects through several pathways: it significantly inhibits key inflammatory biomarkers (VCAM-1, ICAM-1, IP-10, I-TAC, MIG, M-CSF), and downregulates IL-6, TNF-α, and COX-2 expression in dermal fibroblasts. It also demonstrates antiproliferative activity and modulates tissue remodeling by inhibiting collagen-I, collagen-III, PAI-1, TIMP-1, and TIMP-2, which aids in wound healing and reducing the appearance of scars. Furthermore, its major component, alpha-thujone, contributes to antimicrobial, antifungal, and antiviral actions, while a rich flavonoid content provides antioxidant protection. Immunomodulatory effects are also observed through M-CSF inhibition, with tannins offering astringent and cicatrizing benefits.

Research

Clinical Evidence

Medium confidence
Effective range 0.00041% v/v–0.1%%
Optimal

Efficacy observed within 0.00041% to 0.011% v/v for anti-inflammatory and tissue remodeling effects; 0.1% v/v for antimicrobial action.

Transparency

Dusting Analysis

Not commonly dusted

Thuja Plicata Stem Oil exhibits potent biological activity at very low concentrations, making it effective without requiring high percentages. The primary concern is not 'dusting' due to lack of efficacy at low doses, but rather safety at higher concentrations due to its high thujone content. Consequently, responsible formulation mandates significant dilution to prevent irritation and neurotoxicity, implying that any formula featuring this ingredient in more than trace amounts is a significant red flag for safety rather than efficacy.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Specific stability data for cosmetic formulations were not provided.

Conflicts

  • High concentrations are incompatible with skin safety due to potential irritation and neurotoxicity from thujone; requires significant dilution with carrier oils.
  • Incompatible with internal use.
  • Avoid use during pregnancy due to emmenagogue properties.
  • Avoid use with babies, children, and the elderly due to neurotoxicity concerns.

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk Moderate

Thuja Plicata Stem Oil lacks specific CIR, SCCS, or FDA review. It contains high levels of thujone (52.1%-77.5% α-thujone, 4.9%-9.3% β-thujone), which is associated with neurotoxicity. The European Agency for the Evaluation of Medicinal Products (EMEA) suggests a maximum daily thujone intake of 1.25 mg/kg body weight. Due to this, the oil must be used very sparingly and heavily diluted for topical application. It is contraindicated for internal use, during pregnancy, and for infants, children, or the elderly. Despite these concerns, a supplier declaration indicates compliance with EU cosmetic regulations regarding prohibited substances when used appropriately, implying safe use at precise, low concentrations.

Your Skin

Skin Compatibility

No Normal
No Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Thuja Plicata Stem Oil is a valuable ingredient due to its broad anti-inflammatory, antimicrobial, and tissue remodeling benefits, provided it is formulated with extreme precision at very low concentrations to mitigate significant thujone-related safety risks.

Related

Similar Ingredients

Finding similar ingredients…