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Moumoujus

THIOUREA.

Avoid CAS 62-56-6 / ANTIMICROBIAL, HUMECTANT

Thiourea is recognized for its antioxidant properties, with some derivatives demonstrating antimicrobial activity through quorum sensing interference. Despite these potential mechanisms, thiourea is deemed unsuitable for skincare due to significant health risks and regulatory prohibitions.

Summary

Antioxidant

Science

Mechanism of Action

Thiourea functions as an antioxidant. Its derivatives exhibit antimicrobial effects by interfering with bacterial quorum sensing, a communication system that regulates gene expression in bacterial populations.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Thiourea exhibits stability under standard temperatures and pressures.

Conflicts

  • acrylaldehyde (acrolein) (violent exothermic polymerization reaction)
  • hydrogen peroxide and nitric acid (violent decomposition)
  • potassium chlorate (spontaneous explosion upon grinding)
  • sulfhydryl oxidising agents
  • metallic salts
  • many organic compounds including proteins and certain hydrocarbons

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk High

Thiourea is classified as a probable human carcinogen by independent scientific and health experts. Under the Federal Food, Drug, and Cosmetic Act (21 CFR 189.190), any added or detectable level of thiourea in cosmetic products is considered adulterated. Exposure poses a high risk of inducing contact and photocontact allergies in humans. Reports indicate skin penetration and destructive changes in the thyroid gland, including goitrogenic effects from chronic exposure. Furthermore, it may cause disorders in the development of the embryo or fetus.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Thiourea is unequivocally unsuitable for skincare formulations due to its classification as a probable human carcinogen, high sensitization risk, and federal prohibition in cosmetic products.

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