Science
Mechanism of Action
The sulfur atom within Thiodiglycolic Acid's thiol group allows it to function as a reducing agent and an antioxidant, facilitating the formation of new disulfide bonds or breaking existing ones. While its salts are known to disrupt disulfide bonds in hair keratin for waving and depilatory effects, its direct mechanism of action for beneficial skin outcomes in precision skincare remains unexplored in clinical studies.
Research
Clinical Evidence
Insufficient-data confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Thiodiglycolic acid exhibits high stability, resisting photolysis and not expected to undergo hydrolysis. It demonstrates 100% recovery in aqueous solutions across a broad pH range of 4 to 11 over 48 to 96 hours. Its pKa values are approximately 3.32 and 4.29. Decomposition occurs upon heating or contact with acids, releasing toxic sulfur oxides. It is also corrosive to metals.
Conflicts
- metals
- strong oxidizers
- bases
- active metals (e.g., sodium, potassium, magnesium, calcium)
- air (likely to oxidize)
Safety
Safety Profile
Thiodiglycolic acid is classified under GHS H314, indicating it 'Causes severe skin burns and eye damage' and is corrosive. It is known to cause irritation to skin and eyes and is toxic via intraperitoneal administration. Regulatory bodies, such as the New Zealand EPA, permit its use under appropriate group standards rather than individual approval.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Due to its classification as corrosive with a high irritancy potential and the ability to cause severe skin burns, Thiodiglycolic Acid is unsuitable for precision skincare formulations, especially given the lack of demonstrated clinical efficacy for skin benefits.
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