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Moumoujus

TETRAPLEURA TETRAPTERA FRUIT EXTRACT.

Insufficient Data CAS 2131091-72-8 / FRAGRANCE

Tetrapleura Tetraptera Fruit Extract is derived from the Aidan fruit, rich in beneficial phytochemicals. It exhibits promising anti-inflammatory and antioxidant properties, protecting skin from oxidative stress and irritation. While traditionally used, specific topical efficacy and safety data in cosmetic formulations are not extensively documented.

Summary

Antioxidant Anti-inflammatory Antimicrobial Wound Healing (potential)

Science

Mechanism of Action

This extract operates through a multifaceted mechanism, primarily leveraging its rich profile of phenolic compounds, flavonoids, chalcones (such as butein and isoliquiritigenin), and flavanones like naringenin. These phytochemicals impart potent antioxidant capabilities, neutralizing free radicals and mitigating oxidative stress within skin cells. Furthermore, the extract demonstrates anti-inflammatory action by reducing edema, suggesting modulation of inflammatory pathways. Beyond these, it may also contribute to skin regeneration and collagen deposition, potentially aiding in wound healing, and has shown antimicrobial activity against various pathogens.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 An aqueous extract, administered orally at 50-800 mg/kg, significantly reduced acute inflammation (hind paw edema) in rats in a dose-dependent manner, confirming anti-inflammatory effects.
  2. 02 Extracts exhibit significant antioxidant properties, attributed to the presence of phenolic compounds, flavonoids, chalcones, and naringenin.
  3. 03 A water extract of the stem-bark promoted wound healing by improving epithelialization time and tensile strength in rat excision and incision wounds. Histological analysis revealed enhanced collagen synthesis and reduced inflammatory cells.

Transparency

Dusting Analysis

Not commonly dusted

No data available to suggest this ingredient is commonly 'dusted' or used at concentrations beyond its demonstrated efficacy for skin benefits.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The fruit is amenable to both aqueous and ethanolic extraction methods. The intrinsic pH of the fruit ranges from 4.8 to 6.96, while infusions can present a pH between 3.35 and 4.15. No specific optimal pH range for stability in finished cosmetic formulations has been documented.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No dedicated safety assessment for cosmetic use by CIR, SCCS, or FDA was identified. Acute oral toxicity studies in rats indicate low toxicity, with LD50 values exceeding 1000 mg/kg and >5000 mg/kg for various extracts. However, high oral doses (above 400-1000 mg/kg) in rats may impact renal and liver function. An in vitro study showed weak mutagenic activity for a methanol extract of the fruit. The raw fruit naturally contains oxalates, tannins, and hydrocyanic acid, which are generally not present in purified extracts for cosmetic use but warrant consideration for raw material sourcing.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While exhibiting promising antioxidant and anti-inflammatory benefits in preliminary studies, the lack of specific topical concentration data and formal cosmetic safety review necessitates further research for precise application in advanced skincare formulations.

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