Science
Mechanism of Action
Acetyl Tetrapeptide-15 operates by binding to the μ opioid receptor on nerve endings, mimicking the action of endomorphin-2. This mechanism helps to limit the release of pro-inflammatory neuromediators, such as Calcitonin Gene-Related Peptide (CGRP), from sensory neurons, thereby diminishing sensations of pain and discomfort. Additionally, it contributes to improved epidermal barrier homeostasis and exhibits anti-allergenic and anti-inflammatory properties by decreasing pro-inflammatory cytokine expression.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Acetyl Tetrapeptide-15 shows good stability under standard storage conditions but can be sensitive to extreme pH levels or high temperatures. To minimize deamidation and ensure peptide integrity, formulations should ideally be maintained within a pH range of 3 to 5. For extended storage of stock solutions, -80°C for 6 months or -20°C for 1 month is recommended, in sealed containers, away from moisture and light.
Conflicts
- strong oxidizing agents
- strong acids
- heat
Safety
Safety Profile
Acetyl Tetrapeptide-15 has demonstrated a favorable safety profile in in vitro and ex vivo studies, exhibiting minimal cytotoxicity and no phototoxic or allergenic responses at typical concentrations. It is verified to be free of heavy metals and is reported not to cause skin or eye irritation. SkinSAFE classifies it as 'Irritant Free', 'Teen SAFE', 'Lip SAFE', 'Baby SAFE', and 'Eyelid SAFE', with a given FDA Unique Ingredient Identifier (UNII) 6K389LE0MV.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Tetrapeptide-15 is a valuable active ingredient for precision skincare, particularly effective in desensitizing hyper-reactive skin by modulating neuro-sensory responses and improving the skin's tolerance.
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References
Sources