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Moumoujus

TETRANDRINE.

Avoid CAS 518-34-3 / SKIN CONDITIONING

Tetrandrine is a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, primarily investigated for its potent anti-inflammatory, anti-fibrotic, and immunomodulatory properties. Its cellular mechanisms involve calcium channel blocking and key signaling pathway inhibition.

Summary

Skin conditioning Anti-inflammatory Anti-fibrotic Immunomodulatory

Science

Mechanism of Action

Tetrandrine operates as a calcium channel blocker, modulating calcium influx essential for various cellular functions. It exhibits anti-inflammatory effects by inhibiting mast cell degranulation and suppressing the NF-κB pathway, thereby reducing pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6, and IL-8. Additionally, it demonstrates anti-fibrogenic actions by inhibiting fibroblast activation, reducing collagen production, and decreasing pro-fibrotic cytokines like TGF-β. In inflammatory skin contexts, it can promote the expansion of regulatory T cells (CD4+Foxp3+ Tregs) via the TNF-TNFR2 pathway.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro, Tetrandrine (4 µM) demonstrated antiproliferative activity against human A673 cells.
  2. 02 In vitro, Tetrandrine (15.8 µM) showed antiproliferative activity against vincristine-resistant human CEM cells.
  3. 03 In vitro, Tetrandrine (5 µM) induced autophagy in HeLa, MCF-7, and human foreskin fibroblast (HFF) cells.
  4. 04 In vitro, Tetrandrine (5 and 10 µM) pre-treatment of mesenchymal stem cells (MSCs) significantly reduced TNF-α secretion by RAW 264.7 cells in co-culture.
  5. 05 In vitro, Tetrandrine inhibited the growth of human skin fibroblasts in a dose- and time-dependent manner.
  6. 06 Topical application of Tetrandrine nanoemulsion in mice promoted CD4+Foxp3+ regulatory T cell expansion and alleviated imiquimod-induced psoriasis.

Transparency

Dusting Analysis

Not commonly dusted

Tetrandrine is not commonly found or marketed in consumer skincare products; its primary application is within scientific research for its diverse biological activities.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Tetrandrine exhibits poor aqueous solubility, dissolving better in alcohols, ether, and chloroform. Its low water solubility and bioavailability often necessitate advanced nanocarrier delivery systems (e.g., liposomes, microspheres, nanoparticles) for enhanced stability and efficacy in formulations.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Tetrandrine is listed in FDA GSRS and EPA DSSTox, but lacks specific cosmetic safety assessments by CIR or SCCS. General GHS classification indicates 'Danger: Fatal if swallowed' (Acute Tox. 2) and 'Harmful if swallowed' (Acute Tox. 4) for oral routes. Its usage is generally restricted to 'For research use only. We do not sell to patients.'

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

While demonstrating potent biological activities in vitro and in animal models, the absence of cosmetic-specific safety data and severe oral toxicity warnings make Tetrandrine an unsuitable ingredient for topical skincare formulations.

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References

Sources