Science
Mechanism of Action
This compound functions as a reversible inhibitor of tyrosinase, the key enzyme involved in melanin synthesis. Its potency is notable, demonstrating an IC50 of 50 nM, which signifies a strong capability to reduce hyperpigmentation by interfering with the melanin formation pathway.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Tetrahydropyranyloxy Phenol, a tetrahydropyranyl ether, is particularly unstable in acidic environments. Such conditions trigger its deprotection and cleavage, leading to the generation of phenol and, more critically, hydroquinone. It is typically dissolved in an oily phase, often facilitated by anhydrous alcoholic solvents.
Conflicts
- Acidic environments (promotes cleavage and hydroquinone formation)
Safety
Safety Profile
The European Commission, responding to the SCCS/1554/15 opinion, determined that using Tetrahydropyranyloxy Phenol at 3% in face creams is unsafe. This conclusion stems from the formation of hydroquinone at levels of safety concern throughout the product's lifecycle. Consequently, its use in cosmetic products has been banned in the EU, effective July 26, 2021. There is no available information regarding CIR or FDA status.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Tetrahydropyranyloxy Phenol is deemed unsafe for cosmetic applications and should be avoided due to its degradation into hydroquinone and subsequent ban in the EU.
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