Science
Mechanism of Action
This ingredient functions by engaging with Transient Receptor Potential Melastatin 8 (TRPM8) channels present in sensory neurons. This interaction specifically activates the sensation of coolness on the skin, thereby acting predominantly as a sensory agent within cosmetic and personal care products.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Mintlactone maintains stability under acidic and neutral conditions, specifically within a pH range of 1.0 to 7.0, but it undergoes hydrolysis in basic environments. It is vulnerable to oxidation at its double bond and can degrade with prolonged exposure to light, air, or heat. For optimal preservation, storage in a cool, light-protected environment at 2-8°C is recommended.
Conflicts
- strong oxidizers
- salts
- strong acids
- strong bases
Safety
Safety Profile
The Research Institute for Fragrance Materials (RIFM) classified its safety data as 'insufficient' for use as a fragrance, citing contradictory genotoxicity test results and concerns regarding the purity and stability of test materials. Bacterial mutagenicity tests yielded varied results across different batches, including positive findings in TA98. In vivo comet assays were positive in female mice livers but negative in males, while in vitro and in vivo micronucleus tests indicated no chromosomal damage. Its Safety Data Sheet identifies it as 'Harmful if swallowed' (Acute Tox. 4, H302), yet it conforms to the purity specifications set by JECFA.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite its capability to provide a distinct cooling sensation, the 'insufficient data' status from RIFM and conflicting genotoxicity findings warrant a cautious approach for its integration into precision skincare formulations.
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References
Sources