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Moumoujus

TETRAHYDRO-4-METHYLQUINOLINE.

Avoid CAS 19343-78-3 / PERFUMING

Tetrahydro-4-methylquinoline is an aromatic compound primarily employed as a perfuming agent, imparting fragrance to formulations. It lacks direct biological activity on the skin that confers cosmetic benefits, and its inclusion in skincare products is critically questioned due to severe safety implications.

Summary

Perfuming agent

Science

Mechanism of Action

The mechanism of Tetrahydro-4-methylquinoline on the skin is solely attributed to its aromatic properties, functioning as a fragrance component. It does not exhibit specific biological activity that translates into skincare benefits. While certain tetrahydroquinoline derivatives are researched for pharmaceutical applications like reducing oxidative stress or anti-inflammatory effects, these properties are not associated with Tetrahydro-4-methylquinoline itself, with sources like Paula's Choice indicating 'No known benefits' for this ingredient in skincare.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

A related isomer, para-methyl tetrahydroquinoline (CAS 91-61-2), has demonstrated stability in various product types, including creams, hair sprays, powders, shampoos, and soaps, suggesting its viability as a fragrance component in these matrices.

Conflicts

  • Nitrosating systems (due to potential for nitrosamine formation)

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk High

A Safety Data Sheet for Tetrahydro-4-Methylquinoline (CAS 19343-78-3) classifies it as Carcinogenicity Category 1B ('May cause cancer') and Acute toxicity (Oral) Category 3 ('Toxic if swallowed'). European hazard information for a related isomer also indicates it is 'Harmful in contact with skin.' Both Tetrahydro-4-Methylquinoline and its related isomer are known to potentially form nitrosamines in nitrosating systems, requiring notification for downstream users to implement protective measures. Despite an IFRA recommendation for the *related isomer* allowing usage up to 2.0000% in fragrance concentrates, the documented carcinogenicity of Tetrahydro-4-Methylquinoline means there is no established safe concentration for its direct cosmetic application on the skin.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Tetrahydro-4-methylquinoline is an ingredient to be avoided in skincare formulations due to its documented classification as a Category 1B carcinogen, acute oral toxicity, and lack of any established cosmetic benefits for the skin.

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