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TETRABROMOPHENOL BLUE.

Optional CAS 4430-25-5 / HAIR DYEING

Tetrabromophenol Blue, also known as Bromophenol Blue, functions primarily as a vibrant pH indicator, exhibiting a distinct color transition from yellow to blue within a precise pH range. In cosmetic formulations, its main application is as a colorant, particularly utilized in hair care products.

colorant pH indicator

Science

This ingredient operates as a pH indicator by altering its electronic structure in response to proton donation or acceptance. This molecular change leads to a highly conjugated, quinonoid-like form in alkaline conditions, causing a distinct color shift from yellow (below pH 3.0) to blue (above pH 4.6). Its primary utility in cosmetic formulations is centered on its colorant properties, rather than active skin benefits.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Both
Optimal pH 3 – 4.6
0 7 14

Stability

Tetrabromophenol Blue exhibits stability under standard laboratory conditions. Its characteristic pH indicator color transition occurs between pH 3.0 (yellow) and pH 4.6 (blue). For optimal stability, aqueous solutions are not recommended for storage for longer than one day.

Conflicts

  • Undiluted Tetrabromophenol Blue is corrosive to eyes; appropriate dilution is crucial for ocular safety.

Safety

CIR Status
Safe as used
Max tested
0.2%
Sensitization risk Low

Evaluated as safe for use in cosmetics by the CIR Expert Panel and the EU's SCCS, with a maximum on-head concentration of 0.2% in hair coloring products. It is listed by the FDA as an approved cosmetic color additive. Studies indicate a low risk of skin sensitization (up to 2%) and no dermal irritation, though skin staining can occur. While the undiluted form is corrosive to rabbit eyes, it is not considered an ocular irritant when diluted to 2%. It is deemed non-genotoxic.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Optional

Tetrabromophenol Blue is a well-studied and safe colorant, primarily functioning as a pH indicator in hair products, with no direct efficacy for skin benefits in precision skincare formulations.


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