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Moumoujus

TERREIN.

Insufficient Data CAS 582-46-7 / SKIN CONDITIONING

Terrein is an intriguing compound exhibiting a dual biological impact on skin: it reduces melanin synthesis, suggesting potential for addressing hyperpigmentation, and modulates human epidermal keratinocyte proliferation, which may be relevant for conditions involving aberrant cell growth.

Summary

skin brightening anti-pigmentation keratinocyte proliferation inhibitor

Science

Mechanism of Action

Terrein operates via two distinct pathways. Firstly, it decreases melanin synthesis by activating the Extracellular Signal-Regulated Kinase (ERK) pathway, leading to the subsequent down-regulation of Microphthalmia-Associated Transcription Factor (MITF) expression and reduced tyrosinase production. Secondly, it inhibits human epidermal keratinocyte proliferation through the inactivation of ERK and a reduction in the expression of the cyclin B1 and Cdc2 complex, ultimately inducing G2/M cell cycle arrest.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Reduces melanin synthesis by decreasing tyrosinase production, mediated through ERK activation and MITF down-regulation.
  2. 02 Inhibits human epidermal keratinocyte proliferation by inactivating ERK and decreasing the expression of cyclin B1 and Cdc2 complex, leading to G2/M cell cycle arrest.

Transparency

Dusting Analysis

Not commonly dusted

No specific data regarding common dusting practices, thresholds, or potential red flag percentages for Terrein were found in the available research.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Terrein is characterized as a polar, substituted dihydrocyclopentenone, suggesting it is likely water-soluble. However, comprehensive, explicit solubility data in water or oil specifically for cosmetic formulation purposes are not currently available. Optimal pH range and detailed stability notes were not found.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Terrein has not undergone formal safety assessment by the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS). There is no identified specific approval or status by the FDA for Terrein as a cosmetic ingredient.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While Terrein demonstrates promising in vitro biological activities in managing pigmentation and cell proliferation, its practical application in skincare is limited by a significant absence of data concerning effective concentrations, comprehensive safety profiles, and specific formulation parameters.

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