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Moumoujus

TELMESTEINE.

Insufficient Data CAS 122946-43-4 / ANTIOXIDANT

Telmesteine is a synthetic four amino acid peptide designed to support skin's natural defenses and regeneration processes. It functions as an antioxidant and a cell-communicating ingredient, exhibiting notable anti-inflammatory properties.

Summary

Antioxidant Cell-communicating ingredient Skin-identical ingredient Anti-inflammatory Skin regeneration Immune defense stimulation

Science

Mechanism of Action

Telmesteine operates by mimicking thymopoietin, a factor that aids in stimulating skin immune responses and regeneration, particularly as natural thymic factors diminish with age. Its potent anti-inflammatory effects stem from inhibiting the activation of nuclear factor kappa-κB (NF-κB) by blocking key signaling pathways, specifically phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) and IκB kinase (IKK) activities. Furthermore, it acts as an Akt-1 inhibitor, IKKα inhibitor, and MMP9 inhibitor, while also providing antioxidant protection against oxidative stress.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrates significant anti-inflammatory effects by reducing LPS-induced nitric oxide (NO) production in RAW264.7 cells and inhibiting TPA-induced skin inflammation (characterized by reduced skin edema and pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α) in animal models.
  2. 02 As an active component within the multi-ingredient medical device Atopiclair, Telmesteine has shown clinical efficacy in managing mild-to-moderate atopic dermatitis, providing substantial relief from pruritus in adult patients.
  3. 03 Contributes to a multicomponent hydrolipidic film (MAS063DP) that effectively restores skin integrity and physiological function in human partial thickness skin wounds.

Transparency

Dusting Analysis

Not commonly dusted

No data available regarding 'dusting' practices for Telmesteine; it is generally utilized for its active therapeutic and cosmetic properties rather than as a minor adjunct.

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

No specific data on optimal pH range or stability considerations were found in the available research.

Synergies

  • Demonstrated efficacy in a multi-ingredient formulation (Atopiclair) alongside glycyrrhetinic acid and Vitis vinifera extracts for atopic dermatitis treatment.
  • Successfully integrated into a multicomponent hydrolipidic film for skin repair.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Telmesteine is recognized in the EUCOSMETICS inventory as a cosmetic antioxidant. However, it has not undergone specific safety evaluations by the SCCS for roles such as colorant, preservative, or UV-filter, nor has a dedicated CIR safety assessment for its use in skincare been published. Its irritancy, comedogenicity, and sensitization risk are currently unknown.

Your Skin

Skin Compatibility

No Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While Telmesteine exhibits promising anti-inflammatory, regenerative, and antioxidant properties demonstrated in preclinical studies and as part of multi-component medical devices, precise efficacy data for standalone cosmetic concentrations and a comprehensive, independent safety review are currently unavailable, limiting its full evaluation for precision skincare.

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