Science
Mechanism of Action
This extract is observed to neutralize free radicals, showcasing antioxidant capabilities, and mitigates inflammation by inhibiting pro-inflammatory cytokines and enzymes. It also possesses antimicrobial activities and may accelerate skin regeneration (epithelialization). Its bioactivity is attributed to key compounds such as flavonoids (e.g., luteolin, apigenin), tannins, betulinic acid, and naphthoquinones (e.g., lapachol, juglone).
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
While Tectona grandis extracts have a history of traditional uses, robust human topical clinical studies specifically validating the efficacy and safety of the wood extract in cosmetic applications are not available in the provided data.
The Formula
Formulation
Stability
The precise optimal pH range for formulation stability is not explicitly defined, though pH may influence the extract's coloration.
Conflicts
- Sensitive skin types due to a high irritancy and sensitizing potential, particularly from compounds like naphthoquinones.
- Formulations where mutagenicity is a concern, as acetone extracts of Tectona grandis wood tested positive in Ames tests.
- High risk of inducing allergic contact dermatitis.
Safety
Safety Profile
Tectona Grandis Wood Extract has not been formally reviewed by CIR or SCCS, and its FDA dermal toxicity status is 'Search' with no determination. While acute oral toxicity studies in animals showed no toxicity up to 5000 mg/kg, teak wood dust is a documented sensitizer and primary irritant, commonly causing both irritant and allergic contact dermatitis. Furthermore, acetone extracts have been found to be mutagenic to Salmonella typhimurium in Ames tests, representing a significant safety concern for cosmetic use. It is categorized as a fragrance agent with a 'not for flavor use' recommendation.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite observed in vitro bioactivities, the substantial risks of mutagenicity, high irritancy, and sensitization, coupled with the absence of comprehensive safety assessments and specific clinical efficacy data for topical skin application, render Tectona Grandis Wood Extract unsuitable for precision skincare formulations.
Related
Similar Ingredients
Finding similar ingredients…