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Moumoujus

TEA-PHOSPHOADENOSINE PHOSPHOSULFATE.

Insufficient Data / HAIR CONDITIONING

This ingredient is a salt of 3'-Phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring molecule essential for critical sulfation reactions within the skin. It plays a foundational role in maintaining skin hydration and structural integrity.

Summary

hydration skin barrier support structural integrity detoxification

Science

Mechanism of Action

TEA-PHOSPHOADENOSINE PHOSPHOSULFATE functions as a donor of PAPS, a universal sulfate provider crucial for various physiological processes in the skin. These sulfation reactions are vital for the formation and proper function of key macromolecules, such as glycosaminoglycans, which contribute significantly to skin hydration and structural stability. Furthermore, PAPS is implicated in the detoxification and bioactivation of external substances (xenobiotics), suggesting its importance in supporting skin health and barrier function.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 6.5 – 8.6
0 7 14

Stability

The phosphosulfate bond within this compound is highly sensitive to acidic environments. It maintains stability for several days at pH values above 6.5, with solutions at pH 8 demonstrating stability when frozen.

Conflicts

  • acidic environments
  • divalent metal ions (may necessitate chelating agents like EDTA for stability)
  • excess ATP
  • excess Mg2+

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

While TEA-PHOSPHOADENOSINE PHOSPHOSULFATE itself has not been directly evaluated by the Cosmetic Ingredient Review (CIR) Expert Panel, the broader category of 'Adenosine Ingredients' (including Adenosine and its phosphates) has been deemed safe for use in cosmetics. The core active molecule, PAPS, is an endogenous compound fundamental to vital biochemical pathways.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While possessing a strong theoretical foundation for enhancing skin hydration and barrier function via its role as a sulfate donor, specific clinical efficacy and safety data for this ingredient in cosmetic applications are currently lacking.

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