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Moumoujus

TAFLUPROST.

Questionable CAS 209860-87-7 / HAIR CONDITIONING

Tafluprost is a potent synthetic prostaglandin F2α analogue, administered as a prodrug, primarily known for its ophthalmic application in reducing intraocular pressure. Through its active metabolite, tafluprost acid, it has been observed to induce cosmetic changes, specifically enhanced eyelash growth and periorbital skin pigmentation, when used around the eyes.

Summary

Eyelash Enhancer (observed effect from ophthalmic use) Pigmentation Inducer (observed effect on periocular tissue from ophthalmic use)

Science

Mechanism of Action

Upon application, tafluprost is metabolized into tafluprost acid, which acts as a selective agonist for the prostaglandin F (FP) receptor. While its primary ophthalmic function is to increase uveoscleral aqueous humor outflow, the observed effects on eyelash growth and periocular skin pigmentation suggest interaction with hair follicles and melanocytes. The precise mechanism for these skin-related effects in a general topical context beyond the eye remains largely undefined.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

0.0015%

Key findings

  1. 01 Clinical studies on tafluprost ophthalmic solution (0.0015%) consistently report increased length, thickness, color, and number of eyelashes, alongside pigmentation of the periorbital tissue. One study noted a lower incidence of iris or eyelid pigmentation compared to latanoprost.

Transparency

Dusting Analysis

Not commonly dusted

Tafluprost is a pharmaceutical-grade prostaglandin analogue with potent biological activity and significant potential side effects, including permanent iris pigmentation. Its use in cosmetics is subject to strict regulatory scrutiny, exemplified by opinions from bodies like the SCCS, making it unsuitable for casual or 'dusting' inclusion in formulations. Its maximum FDA-approved concentration (0.0015%) is as a prescription ophthalmic drug.

The Formula

Formulation

Solubility
Both
Optimal pH 5.5 – 6.7
0 7 14

Stability

This lipophilic ester is a colorless to light yellow viscous liquid, sparingly soluble in water but soluble in ethanol and methanol. It exhibits thermo-responsive properties, requiring refrigeration (2°C - 8°C) for stability. Preservative-free formulations are commonly utilized to mitigate potential ocular adverse reactions.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.0015%
Sensitization risk Moderate

Tafluprost is FDA-approved as a prescription ophthalmic solution (0.0015%) for specific medical conditions. The SCCS has evaluated prostaglandin analogues, including tafluprost, within cosmetic products due to their potent biological activity and potential for significant adverse effects. Observed side effects include conjunctival hyperemia and ocular irritation (stinging, itching, dry eyes). Crucially for skin, it can induce pigmentation of the iris (potentially permanent) and periorbital tissue, as well as changes in eyelash characteristics (these tissue and eyelash changes have been reported to be reversible in some cases upon discontinuation). Due to pigmentation risks, its use is not recommended for pediatric patients.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Tafluprost is a potent pharmaceutical agent with documented effects on eyelash growth and periocular pigmentation, but its use in cosmetics is highly questionable due to significant safety concerns, including potentially permanent iris pigmentation, and regulatory scrutiny from bodies like the SCCS.

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