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Moumoujus

TABEBUIA AVELLANEDAE BARK POWDER.

Insufficient Data CAS - / SKIN CONDITIONING

Derived from the bark of the Tabebuia avellanedae tree, this powder contains active compounds such as naphthoquinones and flavonoids. Research indicates its potential for broad-spectrum skin benefits, including antioxidant, anti-inflammatory, antimicrobial, and wound-healing properties, alongside possible depigmentation effects.

Summary

Antioxidant Anti-inflammatory Antimicrobial Antifungal Wound Healing Depigmenting Agent Immune Support

Science

Mechanism of Action

This ingredient operates through several sophisticated mechanisms on the skin. Its naphthoquinones (lapachol and beta-lapachone), flavonoids, and phenolic acids contribute to significant anti-inflammatory action by suppressing mRNA expression of T helper 2-specific cytokines (IL-4, IL-5) and key proinflammatory cytokines (IFN-γ, IL-12). As an antioxidant, it neutralizes free radicals, safeguarding cellular integrity. Antimicrobial and fungicidal properties are attributed to its naphthoquinone content, while components like beta-lapachone and lapachol facilitate wound healing by accelerating cell migration and stimulating protein production crucial for tissue repair. Furthermore, beta-lapachone has been identified for its potential to address hyperpigmentation, and the extract may also bolster immune defenses and exhibit antipsoriatic activity by inhibiting specific cell growth.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Bark extract demonstrated significant antioxidant activity in a DPPH assay at an IC50 of 12.13 µg/ml.
  2. 02 Bark extract exhibited antibacterial action (minimal inhibitory concentration) against four bacterial strains, ranging from 3.67-5.83 mg/mL.
  3. 03 Bark extract showed minimum bactericidal concentration against four bacterial strains, ranging from 4.33-7.33 mg/mL.
  4. 04 A Tabebuia avellanedae ethanol extract (Ta-EE) ameliorated atopic dermatitis (AD) symptoms in mice, reducing epidermal thickness, allergic and proinflammatory cytokines (histamine, IgE, IL-4, IFN-γ), and suppressing mRNA expression of T helper 2-specific cytokines (IL-4, IL-5) and proinflammatory cytokines (IFN-γ, IL-12) in AD skin lesions and splenocytes.

Transparency

Dusting Analysis

Not commonly dusted

No specific data available to suggest common dusting practices or associated thresholds for topical applications of this ingredient.

The Formula

Formulation

Solubility
Alcohol
Optimal pH N/A
0 7 14

Stability

Active components are poorly water-soluble but exhibit better solubility in alcohol.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Information regarding the safety and potential side effects of topical application is limited. While generally noted as non-irritating by some sources, there is a warning of potential irritation, inflammation, or dryness, particularly when formulated with other challenging ingredients. High oral doses of Pau d'arco (Tabebuia avellanedae) are considered possibly unsafe, carrying risks such as severe nausea, vomiting, diarrhea, dizziness, and internal bleeding, though these apply to oral rather than topical administration.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While Tabebuia Avellanedae Bark Powder demonstrates a promising array of benefits in preliminary studies, comprehensive human topical efficacy and safety data are currently insufficient to warrant a higher rating for precision skincare formulations.

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