Science
Mechanism of Action
This ingredient functions by delivering a complex array of components from the broken-down cyanobacterial cells to the skin. Pre-clinical studies indicate that the parent organism, Synechococcus elongatus, can promote angiogenesis (new blood vessel formation) and accelerate wound repair, potentially via functional extracellular vesicles and by upregulating interleukin 6 (IL-6) expression. As a broader category of 'lysate filtrates,' it is believed to offer skin rejuvenating and protective advantages by fostering a balanced microbiome, improving skin hydration and elasticity, minimizing the appearance of wrinkles, supporting cellular turnover, and reducing visible redness and irritation. Such lysates frequently contain beneficial compounds like hyaluronic acid for intense hydration, lactic acid for gentle exfoliation, lipoteichoic acid to stimulate antimicrobial peptides, and sphingomyelinase to generate ceramides crucial for barrier repair.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 Research on the organism Synechococcus elongatus PCC 7942 demonstrated significant potential in wound healing and angiogenesis. In mouse studies, treatment with 10^5 cells in 100 μL PBS promoted new blood vessel formation and accelerated burn wound repair. In vitro, the cyanobacterium enhanced the angiogenic activities of endothelial cells, suggesting a direct cellular benefit.
- 02 While specific clinical efficacy data for SYNECHOCOCCUS ELONGATUS LYSATE FILTRATE on human skin is not yet established, broader studies on probiotic ferment lysates offer insights. For instance, a lotion containing 3% of a mixed ferment lysate (Lacticaseibacillus rhamnosus and Lactobacillus paracasei) significantly improved skin moisturization, decreased transepidermal water loss (TEWL), and reduced redness after 30 days of use in a clinical study involving sensitive skin.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
As a water-soluble lysate filtrate, specific optimal pH range for its stability in cosmetic formulations is not detailed in current research. However, the originating organism, Synechococcus elongatus, is known to tolerate alkaline pH levels in its natural habitat. Lysate preparation often occurs in buffered solutions around pH 7.4, suggesting inherent stability across typical cosmetic pH ranges.
Safety
Safety Profile
SYNECHOCOCCUS ELONGATUS LYSATE FILTRATE has not been specifically evaluated by the Cosmetic Ingredient Review (CIR) Expert Panel or the Scientific Committee on Consumer Safety (SCCS). However, other 'ferment lysate' ingredients, such as Lactobacillus Ferment Lysate Filtrate, have been deemed 'safe as used in cosmetics' by the CIR. Safety assessments on the live Synechococcus elongatus organism in rats showed no significant immune response, sepsis, or toxicity. Furthermore, industry experts like Paula's Choice generally classify this ingredient as non-irritating.
Your Skin
Skin Compatibility
Our Assessment
Verdict
With compelling pre-clinical evidence for promoting wound healing and angiogenesis, alongside the established skin conditioning benefits observed in other ferment lysates, this ingredient holds valuable potential for advanced, reparative, and balancing skincare formulations.
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