Science
Mechanism of Action
As a protease, Sutilains function by enzymatically hydrolyzing the protein bonds within the stratum corneum, thereby promoting the exfoliation of dead skin cells. Subtilisin, a component within the sutilains enzyme family, has additionally been investigated for its capacity to inhibit tyrosinase, an enzyme central to melanin synthesis, indicating a potential role in addressing hyperpigmentation.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 A preliminary study of 18 patients observed that sutilains (Travase) ointment provided rapid and effective debridement for burns, decubiti, and traumatic wounds. Efficacy was less predictable for peripheral vascular ulcerations.
Transparency
Dusting Analysis
There is no available data to suggest Sutilains is commonly 'dusted' in cosmetic formulations, nor any specified dusting thresholds or red-flag percentages for this ingredient in a cosmetic context.
The Formula
Formulation
Stability
Sutilains, being an enzyme, exhibits pH-sensitive stability. While a specific optimal pH range for Sutilains itself was not provided, general cosmetic formulations commonly maintain a pH between 4.0 and 6.5 to ensure enzymatic activity and product stability.
Safety
Safety Profile
Sutilains has not undergone review by the Cosmetic Ingredient Review (CIR). While historically listed as a human drug active ingredient (now discontinued) and designated as safe for general or limited food use, its cosmetic safety profile warrants caution. EWG Skin Deep indicates moderate concern for 'Allergies & Immunotoxicity,' with elevated respiratory concerns noted for inhalable product forms. GHS classifications specify that Sutilains 'Causes skin irritation' (H315), 'Causes serious eye irritation' (H319), 'May cause allergy or asthma symptoms or breathing difficulties if inhaled' (H334), and 'May cause respiratory irritation' (H335).
Your Skin
Skin Compatibility
Our Assessment
Verdict
While Sutilains offers benefits as a keratolytic enzyme with potential for skin brightening, its high irritancy potential and the absence of a CIR safety review raise significant concerns for its suitability in precision skincare formulations, particularly for sensitive skin types.
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