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Moumoujus

SUCROSE MYRISTATE.

Valuable CAS 27216-47-3 / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING

Sucrose Myristate is a versatile ester derived from sucrose and myristic acid, primarily recognized for its ability to enhance the permeation of other compounds into the skin. It also functions as an emollient to soften skin and an emulsifier to stabilize cosmetic formulations.

Summary

skin conditioning skin conditioning - emollient surfactant - cleansing surfactant - emulsifying

Science

Mechanism of Action

This ingredient acts as a penetration enhancer, improving the delivery of active substances into the skin. Its amphiphilic nature allows it to serve as an emollient, smoothing and softening the skin, while simultaneously acting as an emulsifying surfactant to create stable mixtures of immiscible liquids like oil and water. It further contributes to skin conditioning, product texture refinement, stability, and enhanced moisture retention.

Research

Clinical Evidence

Medium confidence
Effective range 0.01–2.64%
Optimal

2.64%

Key findings

  1. 01 A 2.64% concentration significantly enhanced the penetration of ibuprofen through excised human epidermis in a hydrogel formulation, demonstrating superior permeation compared to control gels and sucrose laurate gels. This concentration also provided effective and lasting skin moisturization.
  2. 02 In human nasal epithelial cells, concentrations from 0.1 to 3 mg/mL (approximately 0.01% to 0.3%) showed a concentration-dependent increase in paracellular permeability. A non-toxic dose of 0.1 mg/mL (approximately 0.01%) significantly enhanced permeability.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH 3.5 – 6
0 7 14

Stability

Sucrose ester microemulsions exhibit stability within a pH range of 3.5 to 6.0. High temperatures, specifically 170-190 °C, can lead to the degradation of sucrose during synthesis. Emulsion stability may also be reduced if the temperature exceeds the melting point of the surfactant adsorption layer.

Synergies

  • Enhances the penetration and efficacy of other active ingredients in a formulation.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

While specific CIR data for Sucrose Myristate is noted as 'insufficient data', the Cosmetic Ingredient Review (CIR) Expert Panel has broadly concluded that saccharide esters are safe for use in cosmetics under current practices and concentrations. Sucrose fatty acid esters, including Sucrose Myristate, are also approved as direct food additives under 21 CFR 172.859, indicating a favorable safety profile.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Sucrose Myristate is a valuable ingredient for advanced skincare, offering significant penetration enhancement, emollient benefits, and emulsifying capabilities, making it suitable for a wide range of skin types with a low risk of irritation.

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