Science
Mechanism of Action
Operating at the epidermal level, strontium cation, derived from strontium acetate, intercepts irritation signals by interacting directly with nerve cells. This action may involve modulating nerve cell depolarization and repolarization, blocking specific ion channels, or suppressing neurotransmitter release. Consequently, Strontium Acetate exhibits broad anti-irritant, anti-pruritic (anti-itch), and anti-inflammatory effects.
Research
Clinical Evidence
High confidence5%
Key findings
- 01 Clinical studies demonstrate concentrations of 3.08-6.17% strontium acetate (150-300 mM strontium cation) effectively suppress sensations like stinging, burning, tingling, itching, and erythema provoked by irritants such as lactic acid, glycolic acid, capsaicin, and benzoyl peroxide.
- 02 A strontium-based cream significantly reduced pruritus in individuals with Hidradenitis Suppurativa, with 76% reporting decreased overall itch within a week.
Transparency
Dusting Analysis
No data suggests Strontium Acetate is commonly 'dusted' in cosmetic formulations. Its reported effective concentrations indicate it is used at therapeutically relevant levels.
The Formula
Formulation
Stability
As a hygroscopic white crystalline solid, Strontium Acetate absorbs atmospheric moisture. It maintains stability under typical ambient conditions but will lose water at 150°C and decompose into strontium oxide upon further heating.
Conflicts
- Strong oxidizing agents
- Acids (for storage)
- Carbopol (as a thickening agent in low pH strontium salt formulations)
Safety
Safety Profile
While not reviewed by CIR, Strontium Acetate is evaluated and regulated by the SCCS under the EC Cosmetics Regulation (Annex III). Its use in cosmetics is deemed safe when adhering to specified restrictions, which may include purity standards, maximum concentration limits, or specific product category applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Strontium Acetate is a valuable ingredient for precision skincare, effectively reducing various forms of skin irritation and pruritus by modulating nerve cell activity.
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