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STREPTOCOCCUS THERMOPHILUS LYSATE.

Valuable / SKIN PROTECTING

Streptococcus Thermophilus Lysate is a postbiotic ingredient derived from the fermentation of Streptococcus thermophilus, known for its ability to bolster the skin's natural barrier. It actively supports ceramide production, offers significant anti-aging benefits by boosting collagen synthesis and reducing oxidative stress, and provides soothing effects for various skin conditions. This ingredient is meticulously engineered to enhance skin resilience and improve overall skin health.

Summary

Skin-identical ingredient Skin-soothing Antioxidant Barrier repair Anti-aging Anti-inflammatory Collagen synthesis booster Moisturizing Elasticity improvement Pore size reduction Wrinkle depth reduction

Science

Mechanism of Action

This lysate operates by delivering sphingomyelinase, an enzyme crucial for converting sphingomyelin into ceramides within the stratum corneum, thereby reinforcing the skin's lipid barrier and minimizing transepidermal water loss. Beyond barrier restoration, it modulates skin immunity to mitigate inflammation and enhance natural defenses. In vitro investigations reveal anti-fibrotic properties through inhibition of Smad signaling, reduction of β-catenin, and elevation of PPARγ levels. Furthermore, it counteracts cellular aging by neutralizing free radicals, activating antioxidant pathways, increasing fibroblast proliferation, and promoting Type I collagen synthesis, ultimately shielding the skin from external stressors.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Topical application demonstrated an increase in ceramide production within 7 days in patients with acne, exhibiting antimicrobial and anti-inflammatory benefits.
  2. 02 A cream containing sonicated Streptococcus thermophilus improved ceramide concentrations and alleviated symptoms in individuals with atopic dermatitis.
  3. 03 In vitro studies showed that Streptococcus thermophilus lysate at concentrations of 50-100 µg protein/ml significantly reduced Type I collagen levels in TGF-β1-activated normal human dermal fibroblasts, indicating anti-fibrotic activity.
  4. 04 Topical application was associated with reduced pore size and wrinkle depth, alongside enhanced skin moisture and elasticity.
  5. 05 A specific lysate (CNCM I-5570) suppressed H2O2-induced cellular aging markers, increased fibroblast proliferation, promoted collagen I synthesis, and neutralized oxidative stress in human dermal fibroblasts.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The optimal growth pH for the live bacterium is approximately 6.5-7.0. While exopolysaccharides (EPS) from Streptococcus thermophilus have shown stability at high temperatures and low pH, precise optimal pH ranges for the stability of the lysate itself within cosmetic formulations are not explicitly detailed in current research.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While Streptococcus Thermophilus Lysate itself has not been specifically reviewed by CIR, a related ingredient, Lactobacillus Ferment Lysate, was deemed 'safe as used in cosmetics' by CIR. The live bacterium, Streptococcus thermophilus, generally holds a history of safe use in food and some strains are GRAS (Generally Recognized As Safe) by FDA for food applications. Safety assessments of a specific strain (IDCC 2201) indicated no hemolytic activity, absence of toxic substance-producing enzymes, antibiotic susceptibility, and non-toxicity in acute oral tests. Concerns raised by the FDA regarding live S. thermophilus (TH-4®) pertained to oral consumption in probiotic supplements for preterm infants, which does not extrapolate to topical application of the lysate. All cosmetic ingredients in Europe are mandated to adhere to rigorous safety regulations.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Streptococcus Thermophilus Lysate is a highly valuable postbiotic ingredient, offering comprehensive benefits for skin barrier enhancement, anti-aging, and soothing, with excellent skin compatibility and a low risk profile.

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