Science
Mechanism of Action
This ferment deeply hydrates and improves skin texture by promoting efficient nutrient absorption, leading to enhanced softness and elasticity. It actively strengthens the skin's protective barrier through the stimulation of crucial lipid production, specifically ceramides, which increases stratum corneum ceramide levels and reduces transepidermal water loss. Furthermore, it demonstrates potent anti-fibrotic actions by counteracting TGF-β1-induced responses in dermal fibroblasts, subsequently reducing alpha-SMA and fibronectin markers, inhibiting collagen synthesis, and abrogating TGF-β1 gene transcription. Its anti-fibrotic effects are also linked to reducing β-catenin and elevating PPARγ levels. The ferment may also modulate excessive inflammatory responses by activating TLR2/TLR6 pathways, potentially inducing IL-10 secretion.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Topical application improved erythema, scaling, and pruritus in patients with atopic dermatitis.
- 02 Topical treatment significantly increased stratum corneum ceramide levels and decreased transepidermal water loss and capacitance in healthy elderly women.
- 03 Demonstrated anti-fibrotic properties by counteracting TGF-β1-induced fibrotic responses in dermal fibroblasts, reducing alpha-SMA and fibronectin levels, inhibiting collagen synthesis and gel contraction, and abrogating TGF-β1 gene transcription.
- 04 Acted as an anti-fibrotic agent by reducing β-catenin and increasing PPARγ levels.
- 05 Exhibited skin hydration, antioxidative, and pH control effects, alongside cell protective benefits.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
For optimal activity of the live bacteria, Streptococcus thermophilus exhibits optimal growth within a pH range of 6.5 to 7.0. However, bacteriocins produced by this species demonstrate stability across a broad pH spectrum, from 3 to 10. Observations in fermented milk products containing Streptococcus thermophilus show stable pH values between 4.2 and 4.6 during storage, indicating that the ferment's beneficial components remain stable in slightly acidic formulations.
Safety
Safety Profile
Streptococcus Thermophilus Ferment Filtrate possesses an excellent safety profile, generally demonstrating good tolerability with minimal serious side effects reported in clinical studies. Minor individual sensitivities, irritation, or allergic reactions are possible, warranting a preliminary sensitivity test. A specific strain, Streptococcus thermophilus IDCC 2201, was rigorously tested and confirmed safe, showing no hemolytic or β-glucuronidase activity, susceptibility to antibiotics, absence of antibiotic resistance or toxigenic genes, and no significant production of biogenic amines or D-lactate. Streptococcus thermophilus is broadly recognized as safe (GRAS), particularly in food applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A highly valuable probiotic ferment, Streptococcus Thermophilus Ferment excels in robust skin barrier support, deep hydration, and significant anti-inflammatory and anti-fibrotic properties, making it suitable for all skin types with a low risk of irritation.
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References
Sources