Science
Mechanism of Action
This single-chain recombinant peptide is produced through controlled fermentation in E. coli, a precise fusion of the gene from Oligopeptide-133 and sr-Clostridium Botulinum Polypeptide-1. Operating as a sophisticated skin conditioning agent, it initiates cellular signaling pathways that activate the skin's endogenous repair mechanisms. This action stimulates the regeneration of mature skin, fortifies its structural integrity, and significantly contributes to the visible reduction of wrinkles, thereby enhancing both complexion and elasticity. Crucially, this cosmetic ingredient is a tailored fusion peptide and does not function by blocking acetylcholine release at neuromuscular junctions, distinguishing it entirely from botulinum neurotoxins.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 Research on similar recombinant peptides, such as Sr-(Oligopeptide-91 Clostridium Botulinum Polypeptide-1), indicates substantial skin conditioning properties. These benefits include improvements in skin texture, enhanced smoothness, a more uniform complexion, and sustained hydration, resulting in skin that feels notably softer and more supple.
- 02 Other closely related peptides, specifically SR-CLOSTRIDIUM BOTULINUM POLYPEPTIDE-1 SH-OLIGOPEPTIDE-1, have demonstrated the ability to stimulate a gradual regeneration of mature skin, reinforce its underlying structure, and contribute to a visible reduction in wrinkles, along with improvements in skin complexion and elasticity.
Transparency
Dusting Analysis
Specific effective concentrations for SR-(OLIGOPEPTIDE-133 CLOSTRIDIUM BOTULINUM POLYPEPTIDE-1) are not currently available in the provided research data. Therefore, an assessment of common 'dusting' practices or red flag percentages cannot be determined at this time.
The Formula
Formulation
Stability
Detailed optimal pH ranges or comprehensive stability data are not specifically available for SR-(OLIGOPEPTIDE-133 CLOSTRIDINUM BOTULINUM POLYPEPTIDE-1). However, peptides generally require meticulous formulation to preserve their stability and efficacy. By reference, stability studies on the parent 'type-C botulinum toxin' showed robust stability across a broad pH range from 2.7 to 10.2, with inactivation noted at extreme pH values of 1.8 and 12.0. Botulinum toxin preparations are known to be sensitive to various factors including heat, alkaline conditions, mechanical shear forces, and contact with reactive surfaces, suggesting similar careful handling considerations may apply to this peptide.
Safety
Safety Profile
SR-(OLIGOPEPTIDE-133 CLOSTRIDINUM BOTULINUM POLYPEPTIDE-1) has not undergone a specific safety review by the Cosmetic Ingredient Review (CIR) Expert Panel. Nevertheless, general safety assessments for broader categories such as 'Tissue-Derived Proteins and Peptides' or 'Ectodermal-Derived Proteins and Peptides' exist and may encompass similar compounds. Ingredients with analogous structures, like Sr-(Oligopeptide-91 Clostridium Botulinum Polypeptide-1), are generally considered safe for topical cosmetic application. While infrequent, potential side effects such as skin irritation, redness, itching, or localized allergic reactions necessitate the recommendation of preliminary patch testing.
Your Skin
Skin Compatibility
Our Assessment
Verdict
SR-(OLIGOPEPTIDE-133 CLOSTRIDIUM BOTULINUM POLYPEPTIDE-1) represents a valuable, scientifically-designed recombinant peptide with a clear mechanism for enhancing skin regeneration, texture, and elasticity, although direct clinical data for this specific compound remains limited, relying on studies of similar peptides.
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References
Sources