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Moumoujus

SOY HYDROXYETHYL IMIDAZOLINE.

Insufficient Data CAS 70024-77-0 / HAIR CONDITIONING, SURFACTANT - CLEANSING

Soy Hydroxyethyl Imidazoline is a soy-derived ingredient belonging to the imidazoline chemical class. While direct research on its topical skincare efficacy is limited, related compounds suggest potential benefits in forming a protective film and supporting the skin's barrier function.

Summary

Barrier enhancement (hypothesized) Film-forming Hair conditioning Antistatic

Science

Mechanism of Action

As an imidazoline, this compound is expected to possess amphiphilic characteristics, enabling it to act as a film-forming agent on the skin. Insights from studies on 1-(2-hydroxyethyl)-2-imidazolidinone (HEI), a closely related molecule, indicate a mechanism involving the inhibition of heparanase and matrix metalloproteinase 9 (MMP-9). This action is theorized to protect the epidermal basement membrane, potentially leading to improved epidermal barrier function through enhanced water retention and reduced transepidermal water loss.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A related compound, 1-(2-hydroxyethyl)-2-imidazolidinone (HEI), improved epidermal barrier function by increasing water content and decreasing transepidermal water loss in sun-exposed facial skin. This was attributed to inhibiting heparanase and matrix metalloproteinase 9 (MMP-9), protecting the epidermal basement membrane.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Imidazolines as a class are generally thermally stable. This ingredient can be solubilized in aqueous solutions, particularly in acidic conditions where it becomes strongly cationic, and is also soluble in non-polar solvents and mineral oils. However, related long-chain alkyl hydroxyethyl imidazolines exhibit very low water solubility, for example, Oleyl Hydroxyethyl Imidazoline at 2.35 x 10^-3 mg/L.

Conflicts

  • High concentrations (5%) of a related imidazoline (CAS No. 95-38-5) have been observed to cause necrotic effects and corrosive skin responses.
  • Oleyl Hydroxyethyl Imidazoline (CAS No. 21652-27-7), a closely related compound, is classified under GHS as causing severe skin burns and eye damage (H314) in 70.4% of reported cases.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel found insufficient data for this specific soy-derived ingredient, lacking information on its composition, impurities, manufacturing, dermal toxicity, or sensitization/irritation. A group of 'Long-chain alkyl hydroxyethyl imidazolines,' which includes this ingredient, is likely to have moderate acute oral toxicity (LD50 1000-2000 mg/kg bw). While generally not expected to be skin sensitizers or genotoxic, corrosive skin responses have been observed at a 5% concentration for a related imidazoline (CAS No. 95-38-5), and Oleyl Hydroxyethyl Imidazoline is classified as causing severe skin burns and eye damage.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Due to the significant absence of direct clinical efficacy and safety data for topical skin application, coupled with observed corrosive potential for related chemical analogues, Soy Hydroxyethyl Imidazoline is not considered suitable for precision skincare formulations.

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