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Moumoujus

SOPHOCARPINE.

Insufficient Data CAS 6483-15-4 / SKIN CONDITIONING

Sophocarpine is a natural alkaloid demonstrating promising anti-inflammatory, anti-pruritic, and antioxidant properties. Research suggests its potential for soothing irritated skin and alleviating discomfort associated with inflammatory conditions, with indications of enhanced skin penetration through advanced delivery systems.

Summary

Anti-inflammatory Anti-pruritic Antioxidant

Science

Mechanism of Action

Sophocarpine primarily acts through multiple pathways to mitigate skin concerns. Its anti-inflammatory action involves inhibiting NF-κB activation and key MAPK signaling pathways (p38 and JNK phosphorylation), which reduces the expression of inflammatory factors such as iNOS, COX-2, TNF-α, IL-1β, IL-6, and prostaglandin E2. For anti-pruritic and analgesic effects, sophocarpine functions as a potential competitive inhibitor of TRP channels (TRPA1 and TRPV1). Furthermore, it possesses antioxidant properties by activating the Nrf2/HO-1 pathway, thereby reducing oxidative stress.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro studies demonstrate that sophocarpine, at concentrations ranging from 50 to 100 μg/mL, effectively inhibits LPS-induced production of inflammatory markers, including nitric oxide (NO), TNF-α, and IL-6, in RAW 264.7 macrophages.
  2. 02 In a mouse model of inflammatory itch and pain, sophocarpine significantly reduced scratching bouts and wipes, and alleviated SADBE-induced inflammatory reactions, suggesting potent anti-pruritic and analgesic effects.
  3. 03 When delivered via an exosome system, sophocarpine showed enhanced penetration through the stratum corneum into deeper layers of the skin, resulting in significantly greater drug flux and absorption rate.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Specific toxicity and safety assessments for sophocarpine in topical skincare formulations are limited. An oral LD50 exceeding >1000 mg/kg has been reported for a sophocarpine derivative in mice, which provides some toxicological context but is not directly transferable to human topical safety.

Your Skin

Skin Compatibility

No Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Sophocarpine presents promising anti-inflammatory, anti-itch, and antioxidant potential for skincare, though further human topical efficacy and safety studies are required to establish its role as a key ingredient.

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