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Moumoujus

SOLVENT YELLOW 33.

Avoid CAS 8003-22-3 / HAIR DYEING

Solvent Yellow 33 is an oil-soluble quinoline-based dye utilized for imparting a bright greenish-yellow color. Despite its FDA approval for certain external applications, comprehensive research indicates significant safety concerns regarding its use.

Summary

Colorant

Science

Mechanism of Action

This quinoline-based compound functions primarily as a colorant, delivering a distinct greenish-yellow hue. Its oil-solubility facilitates enhanced skin penetration, a factor that may contribute to its documented sensitization potential. Beyond its coloring properties, in vitro studies have suggested potential interference with DNA repair mechanisms, exhibit genotoxicity, and demonstrate endocrine activity in cellular assays.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH 6 – 8
0 7 14

Stability

Solvent Yellow 33 demonstrates stability under typical temperatures and pressures, exhibiting robust thermal resistance up to 300°C and excellent light fastness, rated 6-7 on an ISO scale of 1-8. It remains unaffected by 5% sodium carbonate and 5% hydrochloric acid. Optimal storage involves tight, light-resistant containers in a cool, dry environment.

Conflicts

  • Strong oxidizing agents
  • Strong reducing agents
  • Excess heat

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk High

Solvent Yellow 33 is identified as a potent human sensitizer; concentrations as low as 0.006% (60 ppm) have elicited dermatitis, and a 10% suspension significantly increased sensitization frequency. It carries risks of skin irritation, serious eye damage, and potential harm to breast-fed children. The National Toxicology Program has concluded 'some evidence' of carcinogenicity in animals, classifying it as 'Reasonably Anticipated To Be a Human Carcinogen'. Further concerns include potential damage to the unborn child, suspected impairment of fertility, and reported damage to kidneys, liver, cardiovascular system, immune system, and skin by the Agency for Toxic Substances and Disease Registry. Mutagenicity data exists but remains inconclusive.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to its high sensitization potential, significant irritancy, and numerous severe toxicological risks, Solvent Yellow 33 is strongly advised against for use in precision skincare formulations.

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