Science
Mechanism of Action
The extract functions by delivering a complex of active compounds including phenolic acids, flavonoids, vitamin E, and carotenoids. These phytochemicals exert antioxidant effects by inhibiting prooxidant enzymes, mitigating DNA damage and lipid peroxidation, and suppressing reactive oxygen species (ROS) signaling. Furthermore, it demonstrates anti-inflammatory action through the modulation of cytokine production, specifically reducing IL-6, and exhibits preliminary antiviral potential.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
No information suggests this ingredient is commonly misrepresented or over-promoted in the cosmetic industry. Clinical data is primarily in vitro, limiting direct extrapolation to topical skin efficacy.
The Formula
Formulation
Stability
The active phenolic compounds and alkaloids within the extract may degrade when subjected to elevated drying air temperatures during processing, suggesting sensitivity to heat.
Safety
Safety Profile
Solanum Paniculatum Extract has not been evaluated by the Cosmetic Ingredient Review (CIR) Expert Panel, SCCS, or FDA for cosmetic use. While an in vivo toxicological evaluation of the root extract showed no adverse effects on hematological, biochemical, anatomical, or histopathological parameters, in vitro studies reported cytotoxicity in cancer cell lines (MCF-7 at 30 μg/mL, MDA-MB-231 at 1.87 μg/mL) and an increase in pro-inflammatory IL-1β in HUVEC cells at 3.75 μg/mL. Cytotoxicity has also been indicated in bacterial strains and mice micronucleus tests with other extract forms.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While exhibiting in vitro antioxidant and anti-inflammatory properties by decreasing IL-6, concerns arise from its reported cytotoxicity in certain cancer cell lines and an increase in pro-inflammatory IL-1β in normal endothelial cells at relatively low concentrations, alongside an unreviewed safety status.
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