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SODIUM THIOSULFATE.

Valuable CAS 7772-98-7 / 10102-17-7 / REDUCING

Sodium thiosulfate is a versatile inorganic salt recognized for its anti-inflammatory, antioxidant, and antifungal properties. In skincare, it primarily functions to alleviate irritation and redness, restore skin barrier function, and specifically addresses conditions involving abnormal calcium deposits or fungal infections.

Summary

Antioxidant Anti-inflammatory Antifungal Antibacterial Skin Barrier Support Calcium Solubilizer

Science

Mechanism of Action

Sodium thiosulfate acts as a potent antioxidant, neutralizing reactive species and reducing inflammation. It soothes irritation, redness, and itching, and exhibits antibacterial and antifungal activity. For skin calcifications, it increases calcium solubility by forming calcium thiosulfate, aiding in their resolution. Additionally, it contributes to skin barrier restoration and inhibits the release of inflammatory cytokines, particularly in conditions like atopic dermatitis.

Research

Clinical Evidence

High confidence
Effective range 10–25%
Optimal

N/A

Key findings

  1. 01 Topical formulations ranging from 10% to 25% have demonstrated efficacy in reducing inflammation, irritation, itching, and redness associated with conditions such as eczema, psoriasis, and dermatitis, with twice-daily application.
  2. 02 For digital calcinosis cutis, a 10% topical formulation showed effectiveness for lesions up to 2 mm, while 25% intralesional solutions achieved complete resolution after three monthly sessions, with transient burning as the only reported adverse effect.
  3. 03 Topical applications (10-25%) for ectopic calcifications, often dispersed in Galen's cerate and applied once daily, led to significant clinical and radiological improvements.
  4. 04 It is also utilized as a topical antifungal agent for tinea versicolor (pityriasis versicolor), sometimes in combination with salicylic acid.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 9
0 7 14

Stability

Sodium thiosulfate solutions are generally stable within a pH range of 5 to 9 but are susceptible to decomposition in acidic environments. Elevated temperatures and contact with atmospheric carbon dioxide can accelerate decomposition, releasing sulfur dioxide gas and precipitating elemental sulfur. More dilute solutions are particularly prone to faster decomposition. However, topical formulations at 10-25% have demonstrated stability for at least 6 months when stored below 25°C, with solutions maintaining over 95% initial concentration for 24 hours at room temperature.

Synergies

  • Salicylic Acid (for antifungal treatments)

Conflicts

  • Strong oxidizers (potential vigorous exothermic reactions)
  • Acids (releases sulfur dioxide and/or hydrogen sulfide gas)

Safety

Safety Profile

CIR Status
Reconsideration underway
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel is currently re-evaluating sulfites, including sodium thiosulfate. While the FDA has approved its limited use in food, and systemic forms are approved for specific medical treatments, compounded topical formulations for skin conditions are not FDA-reviewed for safety or efficacy.

Your Skin

Skin Compatibility

Yes Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Sodium thiosulfate is a valuable ingredient for addressing inflammatory skin conditions, fungal infections, and abnormal calcifications, offering a range of benefits with a generally low irritancy profile.

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