Science
Mechanism of Action
Sodium thiocyanate exerts its biological effects by interacting with myeloperoxidase (MPO), an enzyme involved in inflammatory processes and oxidative stress. This interaction facilitates the increased production of hypothiocyanous acid (HOSCN), a reactive species that demonstrates both antimicrobial and antioxidant capabilities. HOSCN selectively targets low-molecular weight protein thiols, which is posited to reduce MPO-associated oxidative damage and subsequent tissue degradation.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Sodium thiocyanate is hygroscopic, meaning it readily absorbs moisture from the air, and is susceptible to degradation by light. It may also decompose upon heating or prolonged exposure to light.
Conflicts
- strong acids
- strong bases
- strong oxidizing agents
- strong reducing agents
- excess heat
- exposure to light
- moist air or water
- metals and some metal compounds (potential to polymerize nitriles)
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) has not assessed Sodium Thiocyanate for topical use. While the FDA classifies it as Generally Recognized As Safe (GRAS) for specific food applications (e.g., component of lactoperoxidase system for dairy shelf-life), this designation does not extend to skincare. Potential topical concerns include mild skin irritation and serious eye damage. Exposure via skin contact or inhalation of dust can be harmful, and chronic exposure has been linked to skin rashes. Notably, sensitization has been observed in both human and guinea pig studies.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Given the absence of specific topical safety data, documented irritation, and sensitization risk, the strategic inclusion of Sodium Thiocyanate in Moumoujus's precision skincare formulations warrants significant caution and further investigation.
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References
Sources