Science
Mechanism of Action
PGA functions primarily as a powerful humectant, drawing and retaining a substantial volume of water—reportedly up to 5000 times its weight—to deliver profound and enduring hydration. It forms a breathable, protective film on the skin's surface, effectively sealing in moisture and preventing transepidermal water loss (TEWL), thereby improving skin suppleness. Beyond direct hydration, PGA actively inhibits hyaluronidase, the enzyme responsible for breaking down the skin's natural hyaluronic acid (HA), which helps to preserve existing HA levels and extend its hydrating benefits. It further bolsters the skin's inherent moisture retention capacity by promoting the accumulation of Natural Moisturizing Factors (NMFs). Additionally, PGA stimulates collagen production, provides antioxidant protection against free radicals, supports cellular regeneration, and exhibits mild tyrosinase inhibition for a brighter complexion.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Demonstrated a water retention multiple 3,500 times greater than hydrolyzed collagen.
- 02 An 8-week study with 31 participants showed a 172% increase in skin hydration and a 43% reduction in water loss within 1 hour, providing 24-hour moisturization. The study also noted a 122% improvement in skin elasticity, a 49% increase in firmness, a 34% reduction in wrinkles, and a 39% decrease in pore appearance.
- 03 Increased natural hyaluronic acid levels and Natural Moisturizing Factors (NMFs), leading to enhanced skin hydration and firmness, and a reduction in wrinkle depth by up to 35%.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Sodium Polyglutamate Crosspolymer exhibits exceptional stability across a wide pH range of 4-10, accommodating both acidic and alkaline formulations. It is also stable against heat and resistant to microbial degradation, which contributes to an extended product shelf life.
Conflicts
- Cationic surfactants (prone to flocculation)
Safety
Safety Profile
Generally regarded as well-tolerated and safe for most skin types, as evidenced by its EWG rating of 1, the safest possible. An ultra-low protein residue manufacturing process significantly minimizes the risk of sensitization. While broadly safe, rare instances of mild irritation may occur in individuals with exceptionally sensitive skin.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Sodium Polyglutamate Crosspolymer is a highly valuable multi-functional ingredient offering superior, long-lasting hydration, significant anti-aging benefits, and enhanced skin resilience across all skin types with a low risk of irritation.
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