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Moumoujus

SODIUM PERSULFATE.

Avoid CAS 7775-27-1 / OXIDISING

Sodium Persulfate is a powerful oxidizing agent primarily utilized in cosmetic formulations for its bleaching capabilities, especially in hair products. While effective for lightening pigments, its strong reactive nature necessitates careful consideration for skin safety.

Summary

Oxidising Agent

Science

Mechanism of Action

Acting as a potent oxidizing agent, Sodium Persulfate generates free radicals, particularly under heat. This oxidative process efficiently breaks down and lightens pigments, making it effective for bleaching applications.

Research

Clinical Evidence

High confidence
Effective range 0.01–0.9%
Optimal

N/A

Key findings

  1. 01 Clinical data indicates Sodium Persulfate acts as a strong skin sensitizer, with an estimated EC3 (concentration causing sensitization in 3% of a population) of 0.9%.
  2. 02 Patch tests at 0.5% (5000 ppm) caused positive sensitization reactions in 5 out of 26 subjects, confirmed upon rechallenge in two subjects.
  3. 03 No sensitization was observed in human studies at a concentration of 0.01% (100 ppm).

Transparency

Dusting Analysis

Not commonly dusted
Red flag below
0.01%

Given its classification as a strong skin sensitizer and high irritancy, Sodium Persulfate is not suitable for 'dusting' or inclusion at sub-therapeutic levels. Concentrations above 0.01% have demonstrated sensitization potential, underscoring the need for strict formulation control for rinse-off applications only.

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 8
0 7 14

Stability

A white crystalline solid, Sodium Persulfate exhibits hygroscopic properties and decomposes slowly in moist air, or rapidly with heat or in ethanol. Its stability is compromised by moisture, heat, ignition sources, shock, friction, and various impurities, including metals and reductants. It is unstable in strong acid and alkaline solutions; optimal pH for solutions ranges from 3-8.

Conflicts

  • Combustible materials
  • Reducing agents
  • Organic materials
  • Sodium peroxide
  • Aluminum
  • Powdered metals
  • Strong bases
  • Alcohols
  • Halides (fluorides, chlorides, bromides, iodides)
  • Most metals and heavy metals
  • Oxidizable materials
  • Other oxidizers

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
6%
Sensitization risk High

The CIR Expert Panel considers Sodium Persulfate safe only for brief, discontinuous use in hair colorants and lighteners, followed by thorough rinsing from hair and skin. Data is insufficient for determining safety in leave-on products or dentifrices. It is classified as a strong skin sensitizer with an estimated EC3 of 0.9%, capable of causing allergic skin reactions, dermatitis, and severe irritation to skin and eyes. There is also a potential for toxicity via skin absorption and sensitization of airways.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to its classification as a strong skin sensitizer, high irritancy, and lack of safety data for leave-on skin applications, Sodium Persulfate is not suitable for precision skincare formulations.

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