Science
Mechanism of Action
This ingredient functions as a bacteriostatic and preservative agent by disrupting bacterial cellular integrity. It induces cytoplasmic leakage, thereby impairing membrane permeability to essential ions like potassium and phosphate. This action ultimately dissipates the proton motive force, uncoupling ATP synthesis from bacterial respiration.
Research
Clinical Evidence
Medium confidence0.2%
Key findings
- 01 Demonstrated efficacy as a bactericide in handwash formulations (referencing p-Chlorocresol, a closely related form).
- 02 Clinical patch testing with p-Chloro-m-cresol (PCMC) at 2% revealed irritant reactions, particularly in individuals with pre-existing multiple patch test sensitivities.
Transparency
Dusting Analysis
As a preservative, Sodium p-chloro-m-cresol is typically incorporated at low percentages for its antimicrobial function rather than as an active ingredient requiring dusting analysis.
The Formula
Formulation
Stability
To maintain stability, this ingredient requires storage in a tightly sealed container within a dry, cool, and well-ventilated environment.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel concluded Sodium p-Chloro-m-Cresol and p-Chloro-m-Cresol are safe at concentrations up to 0.5% in cosmetics, noting that some cresols may increase the dermal penetration of other cosmetic ingredients. European Union cosmetics regulations are more stringent, listing Chlorocresol (often considered interchangeable) at a maximum of 0.2% and prohibiting its use in products applied on mucous membranes. It is classified with severe hazards including skin corrosion, serious eye damage, and skin sensitization.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Given its high potential for severe irritation, skin sensitization, and strict regulatory limits, Sodium p-chloro-m-cresol is not suitable for precision skincare formulations.
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References
Sources