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SODIUM ISOBUTYLPARABEN.

Avoid CAS 84930-15-4 / ANTIMICROBIAL

Sodium Isobutylparaben is the water-soluble sodium salt of Isobutylparaben, primarily incorporated into cosmetic formulations for its critical role as a preservative. It effectively extends product shelf life by inhibiting the growth of harmful microorganisms.

Summary

antimicrobial preservative

Science

Mechanism of Action

This ingredient functions as a weak acid within a formulation, disrupting the metabolic pathways of carbohydrates and lipids in bacteria and fungi. Concurrently, it impairs the integrity of their cellular membranes, thereby preventing microbial proliferation and preserving product quality.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Sodium Isobutylparaben functions as a preservative to prevent microbial growth, not as an active ingredient with dose-dependent skin benefits. Therefore, 'dusting' considerations related to efficacy on skin are not applicable.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Parabens, including Sodium Isobutylparaben, are prone to hydrolysis in strongly alkaline solutions, converting into ionized carboxylic acids. Optimal stability is generally achieved in acidic to neutral pH environments. Factors such as partition coefficient, packaging material composition, and storage temperatures can significantly influence its long-term stability.

Conflicts

  • Highly-ethoxylated compounds
  • Cellulose derivatives
  • Proteins
  • Lecithin
  • Clays
  • Surfactants (specifically polyethoxylated hydrogenated castor oil (PHCO) and polyoxyethylene sorbitan monooleate (PSO), which can diminish its antimicrobial action)
  • Macromolecules
  • Wetting agents

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
0.8%
Pregnancy
Caution
Sensitization risk Moderate

The CIR Expert Panel concludes that Sodium Isobutylparaben, along with other parabens, is safe in cosmetics when the total combined concentration does not exceed 0.8%. However, Isobutylparaben has been classified as a Substance of Very High Concern (SVHC) by the European Chemicals Agency (ECHA) as of January 2023, due to documented endocrine-disrupting properties. European Union regulations restrict its use to a maximum of 0.4% for a single paraben ester in finished products and prohibit its inclusion in non-rinse products intended for children under 3 years. The EU Scientific Committee on Consumer Products (SCCP) has also raised concerns regarding its potential for reproductive toxicity.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given its classification as a Substance of Very High Concern (SVHC) due to endocrine-disrupting properties and reported concerns for reproductive toxicity, Sodium Isobutylparaben should be avoided in precision skincare formulations.

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References

Sources