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Moumoujus

SODIUM IODIDE.

Questionable CAS 7681-82-5 / ANTIMICROBIAL

Sodium Iodide is a compound known for its ability to activate the Nrf2 pathway in human skin, offering protection against UVB-induced damage and reducing inflammation. It also functions as an antimicrobial agent, contributing to overall skin health and product preservation.

Summary

antimicrobial antioxidant anti-inflammatory

Science

Mechanism of Action

This ingredient operates by activating the Nrf2 pathway within human skin cells. This critical cellular defense mechanism enhances protection against damage induced by ultraviolet B (UVB) radiation and reduces the secretion of pro-inflammatory cytokines, specifically IL-6 and IL-8. Furthermore, Sodium Iodide exhibits antimicrobial properties, making it beneficial for both skincare formulations and skin surface ecology.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 6 – 9.5
0 7 14

Stability

Sodium Iodide is a hygroscopic solid that readily deliquesces upon exposure to moist air. While chemically stable at standard room temperatures, product quality may be compromised by light exposure, leading to decomposition and the development of a brown tint due to iodine formation. A 5% aqueous solution typically maintains a pH range of 6.0–9.0 at 25°C.

Conflicts

  • strong acids
  • strong oxidizing agents
  • reactive chemicals
  • steel
  • aluminum
  • zinc
  • copper
  • bromine trifluoride

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

Sodium Iodide is classified as causing skin irritation (Category 2) and serious eye irritation (Category 2A). Prolonged exposure to iodides may induce iodism in sensitive individuals, presenting symptoms such as skin rash, runny nose, headaches, and irritation of mucous membranes; severe cases can include pimples, boils, hives, blisters, or bruising. Ingestion may cause organ damage (specifically to the thyroid) with prolonged or repeated exposure. It is listed by the FDA as an 'ACTIVE' substance under EPA TSCA and in the Food Contact Substances Inventory.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While Sodium Iodide offers potential benefits like UVB protection, anti-inflammatory, and antimicrobial actions, its classification as a skin and eye irritant and the risk of iodism in sensitive individuals, coupled with the absence of a CIR safety review, warrant significant caution in formulation.

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