Science
Mechanism of Action
This 'supercharged' cross-linked hyaluronic acid derivative forms an extensive, 'infinite' mesh structure on the skin, enabling it to bind up to 5 times more water than conventional hyaluronic acid. It functions as a potent humectant, continuously attracting and retaining atmospheric moisture, while simultaneously forming a resilient protective film that dramatically minimizes trans-epidermal water loss (TEWL). Its cross-linked nature provides enhanced resistance to enzymatic degradation by hyaluronidase, ensuring a more durable and sustained hydrating effect. This sustained hydration contributes to improved skin elasticity, refined texture, and a visible reduction in fine lines and wrinkles. Furthermore, it fortifies the skin's natural barrier, offers soothing benefits to calm irritation, and can optimize the absorption of other active ingredients.
Research
Clinical Evidence
High confidence0.01-0.1%
Key findings
- 01 In a topical application, a resilient hyaluronic acid (related to SODIUM HYALURONATE CROSSPOLYMER-5) demonstrated a 27.8% reduction in Trans-Epidermal Water Loss (TEWL). This significantly outperformed High Molecular Weight Hyaluronic Acid, which reduced TEWL by 15.6%, and notably reversed the 55.5% *increase* in TEWL observed with Low Molecular Weight Hyaluronic Acid.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This polymer is sensitive to heat, with extreme pH values (below 4 or above 10) leading to accelerated decomposition. For optimal stability, avoid prolonged exposure to temperatures above 50°C, especially at pH levels outside of the 7.0 range. For example, at pH 7, it remains stable for 2 hours at 70°C or 24 hours at 50°C; at pH 5, stability is 2 hours at 50°C or 24 hours at 40°C; and at pH 9, it is stable for 2 hours at 50°C or 24 hours at 40°C.
Synergies
- Other active ingredients (improves absorption by hydrating skin)
Conflicts
- Strong oxidation agents
- Strong reduction agents
- Polymeric cationic substances (e.g., polyquaternium-4, polyquaternium-10)
- Multivalent metals (e.g., Zn2+, Mg2+)
Safety
Safety Profile
While related ingredients like Hyaluronic Acid and Sodium Hyaluronate have been extensively reviewed and deemed safe by the CIR Expert Panel (re-reviewed 2023), a specific CIR report indicates 'crosslinked Hyaluronic Acid' derivatives like Sodium Hyaluronate Crosspolymer-4 are not explicitly covered. However, Sodium Hyaluronate Crosspolymer-5 is generally regarded as non-irritating, suitable for all skin types, and free from common allergens or irritants according to comprehensive SkinSAFE assessments (e.g., Teen SAFE, Fragrance Free, Paraben Free, Oil Free, Dye Free, Irritant Free). Safety tests for topical application have confirmed tolerability up to 1% concentration.
Your Skin
Skin Compatibility
Our Assessment
Verdict
SODIUM HYALURONATE CROSSPOLYMER-5 is a highly effective, safe, and versatile ingredient, offering superior, long-lasting hydration and significant anti-aging benefits across all skin types, making it a valuable asset in advanced skincare formulations.
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