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SODIUM HYALURONATE CROSSPOLYMER-4.

Essential CAS 781214-94-6 / HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

SODIUM HYALURONATE CROSSPOLYMER-4 is an advanced, cross-linked form of hyaluronic acid engineered with a unique 3D structure. This ingredient excels at delivering prolonged, intense hydration, significantly improving skin elasticity and reducing the appearance of wrinkles by forming a robust moisture reservoir on the skin's surface. Its enhanced stability ensures sustained dermal benefits.

humectant skin conditioning

Science

This innovative cross-linked hyaluronic acid derivative forms a unique three-dimensional 'infinite mesh' on the skin, creating a persistent moisture-binding film. It acts as a continuous hydration reservoir, gradually releasing water to prevent transepidermal water loss and significantly enhance skin elasticity. Its superior cross-linked structure grants it exceptional stability against enzymatic degradation and a remarkable water-binding capacity, up to five times greater than conventional hyaluronic acid. Furthermore, it actively scavenges free radicals and bolsters the skin's natural barrier function.


Research

High confidence
Effective range 0.01–0.1%
Optimal

0.01%

Key findings

  1. 01 Recommended for topical cosmetic products within the 0.01-0.1% concentration range, with safety tests supporting use up to 1%. It provides long-term moisturizing benefits and contributes to wrinkle reduction.
  2. 02 A pilot comparative study demonstrated that topical application of a cross-linked resilient hyaluronic acid significantly reduced transepidermal water loss (TEWL) by 27.8%, a superior outcome compared to the 15.6% reduction observed with high molecular weight hyaluronic acid.
  3. 03 Studies indicate that Sodium Hyaluronate Crosspolymer can enhance skin hydration by up to 62% within a single hour, outperforming high-molecular weight hyaluronic acid.

Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH 5 – 9
0 7 14

Stability

This polymer is heat-sensitive and susceptible to decomposition at extreme pH levels (below 4 or above 10), with heating accelerating this process. It maintains stability for 2 hours at 70°C or 24 hours at 50°C at a neutral pH of 7.

Conflicts

  • strong oxidation agents
  • strong reduction agents
  • polymeric cationic substances (e.g., cationic surfactants, Polyquaternium-4, Polyquaternium-10)
  • multivalent metals (e.g., Zn2+, Mg2+) which can alter the crosslinked network quality

Safety

CIR Status
Not reviewed
Sensitization risk Low

While the Cosmetic Ingredient Review (CIR) Expert Panel's 2023 assessment of hyaluronates explicitly excluded cross-linked hyaluronic acid, this ingredient is widely considered safe for cosmetic use. It is non-toxic, non-irritating, and presents a low risk of allergic reactions, aligning with the established safety profile of related hyaluronates such as Sodium Hyaluronate.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Essential

A highly effective and stable form of hyaluronic acid, it delivers superior, long-lasting hydration and anti-aging benefits across all skin types with a low risk of irritation.


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