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SODIUM HUMATE.

Valuable CAS 68131-04-4 / ABSORBENT, ANTIMICROBIAL, BUFFERING, CHELATING

Sodium humate is a multifaceted humic extract recognized for its significant reparative properties, prominently in wound healing and tissue regeneration, partly mediated through the TGF-β/Smad signaling pathway. It also functions as a broad-spectrum skin protector, offering antioxidant, anti-inflammatory, and moisturizing benefits while providing protection against photoaging. Its diverse actions position it as a potent ingredient for promoting overall skin health and recovery.

Wound Healing Anti-inflammatory Antioxidant Moisturizer Cell Regenerator Detoxifier Antimicrobial Astringent Buffering Agent Chelating Agent UV Protectant (Indirect) Anti-aging

Science

Sodium humate operates through multiple pathways to support skin health and repair. It creates a protective barrier on compromised skin surfaces, aids hemostasis by constricting microvessels, and actively detoxifies by eliminating metal ions and toxins from wound areas. Functioning as both an oxidant and a reductant, it enhances intracellular respiration and promotes cell metabolism, facilitating cell survival and granulation production. Its wound healing effects, potentially mediated through the TGF-β/Smad signaling pathway, involve stimulating cell regeneration and granulation tissue growth, while simultaneously inhibiting inflammatory responses and reducing infection risk. As a natural antioxidant, it combats free radicals to slow down skin aging and offers protection against photoaging by influencing cytokines like IL-6 and IL-1β. Additionally, it acts as a moisturizer by adsorbing and retaining water, and exhibits mild astringent and anti-inflammatory activity, proving beneficial for various inflammatory skin conditions.


Research

Medium confidence
Effective range 0.5–2%
Optimal

N/A

Key findings

  1. 01 Topical application of 0.5%, 1%, and 2% sodium humate accelerated wound contraction in a concentration-dependent manner in rats, with 1% demonstrating significant promotion of wound contraction and re-epithelization.

Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH 9 – 11
0 7 14

Conflicts

  • acidic ingredients

Safety

CIR Status
Not reviewed
Sensitization risk Unknown

Sodium humate has been reported as generally safe and non-toxic in various tests, with an oral LD50 exceeding 12g/kg in rats. However, it may cause eye and skin irritation.


Your Skin

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Valuable

Sodium humate is a valuable multi-functional ingredient demonstrating significant reparative, antioxidant, and anti-inflammatory benefits, particularly for compromised and aging skin, though further human clinical studies would strengthen its comprehensive profile.


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