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Moumoujus

SODIUM HEPAROSAN.

Insufficient Data CAS 1544497-09-7 / HUMECTANT, SKIN PROTECTING, VISCOSITY CONTROLLING

Sodium Heparosan is a non-sulfated polysaccharide, structurally resembling hyaluronic acid, and serves as a biosynthetic precursor to heparin. As a glycosaminoglycan (GAG), it exhibits the capacity to attract and retain water, suggesting a role in skin hydration, potentially functioning as a humectant and film-former.

Summary

Hydration Humectant Film-former

Science

Mechanism of Action

This glycosaminoglycan (GAG) operates by attracting and binding water molecules within the skin, a property shared with its structural analogue, hyaluronic acid. While described as biologically inert in extracellular spaces, its ability to retain moisture contributes to enhanced skin hydration and can form a protective film on the skin's surface.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A clinical trial using a 1000 IU/g topical Heparin gel demonstrated absorption into the stratum corneum (45.3%), deep epidermis (10.9%), and dermis (2.9%) over four weeks, in patients treated for conditions like superficial thrombophlebitis. Note: This study uses Heparin, a related compound, not Sodium Heparosan directly for cosmetic purposes.
  2. 02 Improvements in skin hydration, erythema, itching, and burning were noted in a 12-week study using a Compound Heparin Sodium Allantoin Gel for papulopustular rosacea. This formulation contained Heparin Sodium alongside onion extract and allantoin. Note: This study uses Heparin Sodium, a related compound, not Sodium Heparosan directly for general skincare.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 6 – 8
0 7 14

Stability

Sodium Heparosan exhibits water solubility, with solutions requiring protection from microbial contamination to prevent degradation of the polysaccharide sugars. High temperatures, such as those encountered during autoclaving, should be avoided as they can induce crosslinking and degrade the ingredient. Optimal stability is observed within a neutral to slightly alkaline pH range of 6.0 to 8.0, as acidic conditions can lead to degradation.

Conflicts

  • High temperatures, particularly autoclaving, can cause degradation through crosslinking of the sugars.
  • Microbial contamination can lead to enzymatic breakdown of the polysaccharide structure.
  • Potential for charge-based incompatibilities with certain cationic ingredients, inferred from Heparin Sodium's known precipitation with various intravenous medications.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

While the Cosmetic Ingredient Review (CIR) Expert Panel has assessed related glycosaminoglycans such as monosaccharides, disaccharides, and hyaluronates, concluding their safety in cosmetics, Sodium Heparosan itself has not been specifically reviewed by the CIR, SCCS, or FDA for cosmetic use.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While Sodium Heparosan demonstrates a promising mechanism for skin hydration as a glycosaminoglycan similar to hyaluronic acid, there is insufficient direct cosmetic efficacy and safety data to definitively recommend its inclusion in formulations at this time.

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